Article Figures & Data
Figures
- Fig.1. Expression of MK and ER-β proteins in NSCLC, and the corresponding paraneoplastic and normal lung tissue (En Vision Method).
X, Y, Z (negative controls): No staining in NSCLC tissue (×200), paraneoplastic (×200) and normal lung tissue (×100), respectively; P1 (MK positive control): The section of MK strong expression (×400), P2 (ER-β positive control): ER-β positive expression in nuclei of breast cancer cells in breast cancer tissue (×200); A1 : MK diffuse expression in cytoplasm of lung cancer cells in moderately differentiated squamous cell carcinoma of the lung ( ×200), A2: ER-β positive expression in nuclei of lung cancer cells in moderately differentiated squamous cell carcinoma of the lung (×200); B1: MK positive expression in the cytoplasm of lung cancer cells in poorly differentiated squamous cell carcinoma of the lung (×400), B2: ER-β positive expression in nuclei of lung cancer cells in poorly differentiated squamous cell carcinoma of the lung (×200); C1: MK strong expression in cytoplasm of lung cancer cells in moderately differentiated adenocarcinoma of the lung (×400), C2: ER-β positive expression in nuclei of lung cancer cells in moderately differentiated adenocarcinoma of the lung (×200); D1: MK positive expression in cytoplasm of lung cancer cells in poorly differentiated adenocarcinoma of the lung (×400), E1: MK weak expression in paraneoplastic lung tissue ( ×200); D2, E2: ER-β positive expression in nuclei of bronchial epithelial cells in paraneoplastic (×200) and normal lung tissue (×100)
Tables
- Table 1.
The relationships between MK, ER-β expression in NSCLC and the clinicopathological data.
Characteristic Cases (n) MK expression ER-β expression - + Positive (%) - + Positive (%) Sex Male 19 2 17 89.5 5 14 73.7 Female 5 1 4 80.0 3 2 40.0 Age (years) < 65 11 2 9 81.8 3 8 72.7 ≥ 65 13 1 12 92.3 5 8 61.5 Megascopic type Central 14 2 12 85.7 4 10 71.4 Peripheral 10 1 9 90.0 4 6 60.0 Tumor size (cm) < 5 11 1 10 90.9 3 8 72.7 ≥ 5 13 2 11 84.6 5 8 61.5 Histological type Squamous cell carcinoma 7 0 7 100 1 6 85.7 Adenocarcinoma 17 3 14 82.4 7 10 58.8 Pathological classification I/II 15 0 15 100 2 13 86.7 III 9 3 6 66.7* 6 3 33.3* TNM stage I/II 19 3 16 84.2 8 11 57.9 III/IV 5 0 5 100 0 5 100 Regional lymph node metastasis Yes 13 3 10 76.9 4 9 69.2 No 11 0 11 100 4 7 63.6 ↵* P < 0.05 compared with I/II pathological classification.
- Table 2.
The statistical analysis of expression levels of MK and ER-β in NSCLC, and the corresponding paraneoplastic and normal lung tissue.
Group MK ER-β χ2 P χ2 P NSCLC tissue vs. Paraneoplastic tissue 11.021 0.001** 5.333 0.021* NSCLC tissue vs. Normal tissue 14.722 0.000*** 8.392 0.004** Paraneoplastic tissue vs. Normal tissue 0.356 0.551 0.403 0.525 MK ER-β P rs + - + 16 5 0.007 0.535 - 0 3
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