The Inhibitory Effect of Endostatin and Doxycycline Administration on B16 Melanoma Angiogenesis and Cellular Proliferation

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Fig.1.
C group, MVD in the tumor tissue is greater, and the number of necrotic tumor cells less than other groups (S-P method, × 400).
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Fig.2.
DE group, MVD in the tumor tissue is less, and the number of necrotic tumor cells greater than other groups (S-P method, × 400).
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Fig.3. PCNA immunohistochemical staining.
1, C group; 2, D group; 3, E group; 4, DE group (S-P method, × 400).

Table 1.

Necrosis rate, MVD, PCNA positive expression rate in 4 groups.

Group	n	Necrosis rate	MVD	PCNA positive expression rate
DE	15	53.650 ± 22.629^*	10.636 ± 4.411^*	27.586 ± 5.429^*
E	14	32.65 ± 11.081	12.182 ± 4.976^*	49.757 ± 10.780^*
D	14	34.250 ± 9.210	12.167 ± 5.557^*	50.075 ± 12.506^*
C	14	20.075 ± 10.818	21.714 ± 6.182	67.380 ± 5.372