Detection of Homozygous Deletions and Mutations in the CDKN2A Gene in Hydatidiform Moles

Jing Wang; Shuying Wu; Ying Gu; Yan Zhu; Xiaowei Zhang

doi:10.1007/s11805-008-0099-y

Research ArticleResearch Article

Detection of Homozygous Deletions and Mutations in the CDKN2A Gene in Hydatidiform Moles

Jing Wang, Shuying Wu, Ying Gu, Yan Zhu and Xiaowei Zhang

Chinese Journal of Clinical Oncology April 2008, 5 (2) 99-102; DOI: https://doi.org/10.1007/s11805-008-0099-y

Jing Wang

1Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing 100083, China.

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Shuying Wu

1Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing 100083, China.

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Ying Gu

2Department of Genetics, Beijing Haidian Maternal and Child Health Hospital, Beijing 100080, China.

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Yan Zhu

3Department of Gynecology and Obstetrics, Affiliated First Hospital of Liaoning Medical College, Jinzhou 121001, Liaoning province, China.

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Xiaowei Zhang

1Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing 100083, China.

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For correspondence: zhangxw{at}bjmu.edu.cn

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Fig.1. PCR amplication products of the p16^INK4a exon 1 and β-actin.
P16^INK4a exon 1 amplified products of hydatidiform mole samples numbered as 10 and 12 failed to be detected while their β-actin products were well amplified.
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Fig.2.
DHPLC detection for p16INK4a exon 1 amplication products.

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Chinese Journal of Clinical Oncology

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Detection of Homozygous Deletions and Mutations in the CDKN2A Gene in Hydatidiform Moles

Jing Wang, Shuying Wu, Ying Gu, Yan Zhu, Xiaowei Zhang

Chinese Journal of Clinical Oncology Apr 2008, 5 (2) 99-102; DOI: 10.1007/s11805-008-0099-y

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Detection of Homozygous Deletions and Mutations in the CDKN2A Gene in Hydatidiform Moles

Jing Wang, Shuying Wu, Ying Gu, Yan Zhu, Xiaowei Zhang

Chinese Journal of Clinical Oncology Apr 2008, 5 (2) 99-102; DOI: 10.1007/s11805-008-0099-y

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Keywords

hydatidiform mole
CDKN2A gene
homozygous deletion
mutation

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