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Research ArticleResearch Article

Studies on the Expression of MMP-9 and Significance of a Macrophage Assay in Oral Squamous Cell Carcinoma

Taiming Dai, Yufeng Song, Hong Ma and Hongchao Feng
Chinese Journal of Clinical Oncology October 2007, 4 (5) 333-337; DOI: https://doi.org/10.1007/s11805-007-0333-z
Taiming Dai
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China.
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Yufeng Song
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China.
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  • For correspondence: syf1962{at}gmc.edu.cn
Hong Ma
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China.
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Hongchao Feng
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China.
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Article Figures & Data

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    Fig.1.

    Expression of MMP-9 in OSCC (SABC×400).

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    Fig.2.

    Expression of MMP-9 in normal oral tissue (SABC×400).

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    Fig.3.

    Expression of CD68 in OSCC (SABC×400).

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    Fig.4.

    Expression of CD68 in normal oral tissue (SABC×400).

Tables

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    Table 1.

    The expression of MMP-9 in different oral tissues.

    Tissue typesCasesExpression of MMP-9Positive rate %χ2P
    PositiveNegative
    Normal mucosa103730.005.203<0.05
    OSCC42291369.05
    • View popup
    Table 2.

    Correlation between the expression of MMP-9 and clinical indices in OSCC.

    ItemCasesPositive expression of MMP-9 (%)χ2P
    Sex5.347<0.05
         Male2420 (83.33)
         Female189 (50.00)
    Age0.001<0.05
         <60 years2618 (69.23)
         ≥60 years1611 (68.75)
    Lymphatic metastasis6.439<0.05
         No2715 (55.56)
         Yes1514 (93.33)
    Clinical stages4.617<0.05
         Stage I and II136 (46.15)
         Stage III and IV2923 (79.31)
    • View popup
    Table 3.

    The mean macrophage count in different tissues.

    ClassificationCasesAverage macrophage count (Embedded Image)tP
    Normal mucosa OSCC107.10±1.19728.536<0.01
    4242.05±7.548
    SqCa metastasis1548.67±8.4154.872<0.01
    No SqCa metastasis2738.41±3.544
    Stage I and II SqCa1337.46±5.190-2.857<0.01
    Stage III and IV SqCa2944.10±7.599
    • Note: SqCa means squamous carcinoma

    • View popup
    Table 4.

    The relationship between the expression of MMP-9 and macrophage count in OSCC.

    Expression of MMP-9CasesAverage macrophage count
    (Embedded Image)
    tP
    Positive2943.86±8.1843.325<0.01
    Negative1338.00±3.559
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Cancer Biology and Medicine: 4 (5)
Chinese Journal of Clinical Oncology
Vol. 4, Issue 5
October 2007
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Studies on the Expression of MMP-9 and Significance of a Macrophage Assay in Oral Squamous Cell Carcinoma
Taiming Dai, Yufeng Song, Hong Ma, Hongchao Feng
Chinese Journal of Clinical Oncology Oct 2007, 4 (5) 333-337; DOI: 10.1007/s11805-007-0333-z

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Studies on the Expression of MMP-9 and Significance of a Macrophage Assay in Oral Squamous Cell Carcinoma
Taiming Dai, Yufeng Song, Hong Ma, Hongchao Feng
Chinese Journal of Clinical Oncology Oct 2007, 4 (5) 333-337; DOI: 10.1007/s11805-007-0333-z
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Keywords

  • Oral squamous cell carcinoma
  • matrix metalloproteinase-9
  • macrophage
  • immunohistochemistry

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