Research ArticleResearch Article

Relation of Cystatin C and Cathepsin B Expression to the Pathological Grade and Invasion of Human Gliomas

Kai Fan, Yanli Zhang, Dawei Song, Yuchun Zhang and Jianmei Ma
Chinese Journal of Clinical Oncology October 2007, 4 (5) 303-306; DOI: https://doi.org/10.1007/s11805-007-0303-5

Article Figures & Data

Figures

  • Fig.1.
    Fig.1.

    Left: immunohistochemical staining for cystatin C in gliomas (WHO Grade I, 400×). Right: immunohistochemical staining for cystatin C in glioblastomas (WHO Grade IV, 400×). Cystatin C was expressed in the cytoplasm and on the cell membrane of tumor cells. There was more extracellular than intracellular staining. No expression was apparent in the nuclei. The expression of cystatin C in Grade IV was significantly weaker than that in Grade I.

  • Fig.2.
    Fig.2.

    Left: immunohistochemical staining for cathepsin B in gliomas (WHO Grade I, 400×). Right: immunohistochemical staining for cathepsin B in glioblastomas (WHO Grade IV, 400×). Cathepsin B was expressed in the cytoplasm and on the cell membrane of tumor cells as well as in the stromal tissue. The expression of cathepsin B in Grade IV was significantly stronger than that in Grade I.

Tables

  • Table 1.

    Scores of cystatin C and cathepsin B expression in gliomas.

    GradeCases
    (n)    		Cystatin C ScoresCathepsin B Scores
    0~34~60~34~6
    I92781
    II20515182
    III1410459
    IV14122212
  • Table 2.

    Comparision of cystatin C and cathepsin B expression in gliomas.

    Cystatin C ScoresCathepsin B Scores
    GradeCases (n)0~34~6Pχ20~34~6Pχ2
    I~II297220.0001-2630.0001-
    III~IV28226-16..889721-24.429
  • Table 3.

    Relationship between cystatin C and cathepsin B expression in gliomas.

    Cystatin C Scores
    Cathepsin B Scores0~34~6Pr
    0~312210.01
    4~6177--0.34
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