Traumatic Neuromas in Breast Cancer Patients after Mastectomy

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Fig.1.
Small and medium size nerve fibre bundles, which were disordered, oriented and well circumscribed in fibro-adipose tissue (H & E stain, X100).

Table 1.

Clinical features for six cases of traumatic neuroma after mastectomy.

Case number	Age of diagnosis of neuroma	Period of neuroma after mastectomy	Palpable masses	Pain	Location	Ultrasound
1	68y	7.5 y	One nodule 0.7 cm^{^Φ}	-	Close to the mastectomy scar	Well circumscribed, homogeneous, hypo-echoic subcutaneous nodular lesion
2	45y	2.83 y	Three nodular masses 0.8cm; 0.6cm; 0.4 cm^{^Φ}	-	Close to the mastectomy scar	Three well defined, homogeneous, hypo-echoic nodules,
3	57y	8 y	One nodule 0.5×0.7 cm	-	Subclavicular	Poorly defined hypo-echoic nodule with good conduction
4	43y	4 y	One nodule 1.0 cm^{^Φ}	-	Axilla	Poorly defined hypo-echoic nodule with good conduction
5	41y	8 y	One nodule 1.0 cm^{^Φ}	-	Subclavicular	Homogeneous, hypo-echoic subcutaneous nodular lesion
6	52y	3 y	One nodule 0.9 cm^{^Φ}	-	Close to the mastectomy scar	Well defined, homogeneous, hypo-echoic subcutaneous nodular lesion

Table 2.

The diagnosis and treatment of breast cancer for each patient.

Case number	Age at diagnosis of breast cancer	Tumor size (cm)	Stage	Surgical treatment	Lymph nodes metastasis	Chemotherapy	Radiotherapy	ER	PR	TAM
1	61y	2×2	T1N0M0	RM	0/19	CU, 4 cycles	-	+	+	+
2	45y	3.5×3.5	T2N0M0	MRM	0/24	CMF, 6 cycles	Only Internal mammary area	-	-	-
3	49y	4×4	T2N1M0	MRM	4/20	CEF, 6 cycles	+	+	-	+
4	39y	2.5×2.5	T2N0M0	MRM	0/18	CEF, 4 cycles	-	+	+	+
5	33y	1.5×1.5	T1N0M0	MRM	0/15	-	-	-	-	-
6	49y	5×4	T2N1M0	MRM	3/10	CEF, 6 cycles	+	-	+	+

Histopathology: all invasive ductal carcinoma. RM: radical mastectomy MRM: modified radical mastectomy.
CMF: cyclophosphamide/methotrexate/fluorouracil CU: colchicine/uraphetine CEF: cyclophosphamide/epirubicin/fluorouracil
+: positive or with treatment -: negative or without treatment TAM: tamoxifen treatment.