Research ArticleResearch Article

Survivin Antisense Oligodeoxy-Nucleotid Induces Apoptosis in Leukaemia Cell Line K562

Lijun Chen, Qiuyue Jin, Hong Xie, Ruimin Wang and Li Yao
Chinese Journal of Clinical Oncology December 2006, 3 (6) 437-441;

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  • Table 1.

    Growth inhibitory rates of K562 cells treated with survivin ASODN (x±s )

    Groups (concentration nmol/L)A570 (n=8)Inhibitory rates (%)
    Blank control group0.232 ± 0.024-
    Control group1.150 ± 0.233-
    Lipofectin control group1.164 ± 0.124-
    Scrambled ODN group 8001.102 ± 0.093-
    Survivin ASODN group 2000.974 ± 0.03215.80 ± 1.55
    Survivin ASODN group 4000.815 ± 0.061*23.78 ± 5.87
    Survivin ASODN group 6000.73 ± 0.0240*37.09 ± 5.58
    Survivin ASODN group 8000.577+ 0.024*50.64 ± 8.60
    Survivin ASODN group 10000.274 ± 0.015*77.26 ± 2.51

    • ↵* P<0.01 vs. control group

  • Table 2.

    Effect of survivin ASODN on caspase-3 activity of K562 cells (x±.s)

    Groups (concentration nmol/L)A570 (n=8)△A
    Control group0.055 ± 0.003-
    Scrambled ODN group 8000.062 ± 0.003-
    Survivin ASODN group 6000.180 ± 0.0170.111 ± 0.019*
    Survivin ASODN group 8000.770 ± 0.0470.693 ± 0.049*
    Survivin ASODN group 10000.480 ± 0.0230.403 ± 0.022*

    • ↵* P<0.01 vs. control group

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