Research ArticleResearch Article

A Pilot Study of Chronochemotherapy for Nasopharyngeal Carcinoma

Jinling Ou-Yang and Feng Jin
Chinese Journal of Clinical Oncology December 2006, 3 (6) 423-427;

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Tables

  • Table 1.

    Characteristics of the patient cohort

    CC groupRC groupP
    Sex>0.05
    Male1821
    Female129
    Medium age (yr) (range)53 (34~70)56 (32~69)>0.05
    KPS>0.05
    >701213
    50~701817
    Pathology>0.05
    Poorly differentiated2527
    Moderate differentiated52
    Well differentiated01
    Stage>0.05
    I/II54
    III/IV2526
  • Table 2.

    The treatment response in both groups (%)

    GroupnCRPRSDPDCR (%)P(CR+PR)%P
    CC3011181011(36.7)<0.0529 (96.7)<0.05
    RC30616806 (20.0)22 (73.3)
  • Table 3.

    The treatment response analysis according the stage

    StageGroupnCRPRSDPDCR (%)P(CR+PR)%P
    I/IICC541004 (80.0)>0.055 (100)>0.05
    RC422002 (50.0)4 (100)
    III/IVCC25717107 (28.0)>0.0524 (96.0)<0.05
    RC26414804 (15.4)18(69.2)
  • Table 4.

    The immunological parameters before and after chemotherapy in both groups (x±s)

    GroupCD3CD4CD8CD19CD 16+56CD4/CD8T+B+NK
    CCP<0.01P<0.05P<0.05P>0.05R>0.05P<0.05P<0.01
    Before62.1 ± 8.727.5 ± 10.033.1 ± 13.69.1 ± 4.717.4 ± 10.11.1+ 0.787.9 ± 7.6
    After68.3± 7.431.2 ± 5.529.6 ± 6.29.3 ± 2.619.4 ± 8.61.3 ± 0.393.9 + 6.7
    RCP>0.05P>0.05P>0.05P>0.05P> 0.05P> 0.05P> 0.05
    Before64.5 ± 9.829.0 ± 9.831.01 ± 12.79.1 + 6.214.7 ± 10.81.0+ 0.684.3 ± 10.6
    After66.3 ± 8.230.5 ± 7.630.1 ± 9.08.8 ± 3.916.5 ± 9.11.1 ± 0.486.0 ± 9.8
  • Table 5.

    The blood toxic effects in both groups (n/%)

    Grade
    GroupnParametersIIIIIIIVTotal (n/%)
    CC30WBC9/30.04/13.3--13/43.3
    Hb7/23.32/6.7--9/30.0
    Plt7/23.31/3.3--8/26.7
    RC30WBC13/43.38/26.73/10.0-24/80.0
    Hb9/30.05/16.72/6.7-16/53.3
    Pit15/50.02/6.7--17/56.7
  • Table 6.

    Other toxicities in this study

    GroupnAlopeciaRenal dysfunctionLiver dysfunctionPhlebitis
    CC307221
    RC3015232
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