MDRl/P-Glycoprotein Overexpression in Bladder Transitional Cell Carcinoma and its Correlation with Expression of Survivin and Fas

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Fig. 1.
Survivin positive expression in grade 2 BTCC (x 400).
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Fig. 2.
Fas positive expression in normal bladder (x 200).
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Fig. 3.
Fas positive expression in grade 2 BTCC (x 200)
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Fig. 4.
P-GP positive expression in grade 2 BTCC (x 200).

Table 1.

Expression of P-gp, survivin and Fas in BTCC and correlation with clinical pathological characteristics

Clinical pathological parameters		Case (n)	P-GP (%)	Survivin (%)	Fas (%)
Sex	Male	49	26 (53.1%)	46(93.9%)	24(48.9%)
	Female	15	8 (53.3%)	14(93.3%)	8(53.3%)
χ²			0.985	0.939	0.087
Coefficient			0.020	0.106	0.037
Age	<55	21	10 (47.6%)	19(90.5%)	10(47.6%)
	>55	43	24 (55.8%)	41(95.3%)	22(51.1%)
χ²			0.381	0.572	0.071
Coefficient			0.077	0.094	0.033
Grading	G1	12	3(25.0%)	9(75.0%)	5(41.7%)
	G2	28	11(39.3%)	27(96.4%)	13(46.4%)
	G3	24	20(83.3%)**	24(100%)**	14(58.3%)
χ²			14.760	9.143	1.143
Coefficient			0.433	0.354	0.132
Stage	T0-1	42	22(52.4%)	38(90.5%)	20(47.6%)
	T2-4	22	12(54.5%)	22(100%)	12(54.5%)
χ²			0.027	2.235	0.277
Coefficient			0.021	0.184	0.066
Tumor No	One	24	11(45.8%)	22(91.7%)	10(41.6%)
	Multiple	40	23(57.5%)	38(95%)	22(55.0%)
χ²			0.820	0.284	1.067
Coefficient			0.112	0.067	0.128
Recurrence	Primary	48	19(39.5%)	44(91.6%)	21(43.7%)
	Recurrent	16	15(93.7%)**	16(100%)	11(68.7%)
χ²			14.139	1.422	3.000
Coefficient			0.425	0.147	0.212
Total			34(53.1%)	60(93.8%)	32(50.0%)