Research ArticleResearch Article

Activation of NF-κB in Human Breast Cancer and its Role in Cell Proliferation and Progresssion

Chunyou Cai and Zhi Yao
Chinese Journal of Clinical Oncology February 2006, 3 (1) 5-10;

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  • Table 1.

    Clinico -pathological data for 60 breast cancer cases

    AgeER
    <5033Positive24
    ≥5027Negative36
    Lymph node metastasis*HER2
    Positive36Positive30
    Negative24Negative30
    Tumor sizeNF-κB activation**
    <2 cm17Positive30
    ≥2 cm43Negative30
    Histological gradePCNA score
    I1402
    II32138
    III14220

    • ↵* NF-κB activation was significantly correlated with lymph node metastasis (P=0.03).

    • ↵** NF-κB activation was significantly correlated with the level of PCNA (P<0.01).

  • Table 2.

    NF-κB activation in 60 breast cancer cases with different status of ER and HER2 expression

    GroupnPositive rate (%)
    ER-/HER2+*1877.8(14/18)
    ER-/HER2-1833.3 (6/18)
    ER+/HER2+1241.7 (5/12)
    ER+/HER2-1241.7 (5/12)

    • ↵* vs. ER-/HER2-, ER+/HER+ and ER+/HER2- groups (P<0.01 ).

  • Table 3.

    NF-κB activation in 60 breast cancer cases with different histological grades

    Histological gradenPositive rate (%)
    I1435.7(5/14)
    II*3250.3(17/32)
    III**1457.1(8/14)

    • ↵* vs. Histological grade I(P<0.05).

    • ↵** vs. Histological grade I(P<0.05)

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