Research ArticleOriginal Article
Open Access
Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin and Jiangbin Ye
Cancer Biology & Medicine September 2026, 23 (9) 1303-1319; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0444
Xin Jin
1Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin 130000, China
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Albert M. Li
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
Man Zhao
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Haowen Jiang
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Yiren Xiao
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Michaela Yip
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Stavros Melemenidis
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Scott Jackson
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Yanan Yang
4Agilent Technologies, Santa Clara, CA 95051, USA
Cathyrin Simmermaker
4Agilent Technologies, Santa Clara, CA 95051, USA
Meng-Ning Zhou
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Subarna Sinha
5Department of Computer Science, Stanford University, Stanford, CA 94305, USA
Daniel J. Cuthbertson
4Agilent Technologies, Santa Clara, CA 95051, USA
Erinn B. Rankin
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
6Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
Jiangbin Ye
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA

References
- 1.↵
- 2.↵
- Li AM,
- Ye J.
- 3.↵
- Locasale JW.
- 4.
- 5.↵
- Fan J,
- Ye J,
- Kamphorst JJ,
- Shlomi T,
- Thompson CB,
- Rabinowitz JD.
- 6.↵
- 7.
- 8.↵
- 9.↵
- Tibbetts AS,
- Appling DR.
- 10.↵
- 11.↵
- 12.↵
- Ye J,
- Fan J,
- Venneti S,
- Wan YW,
- Pawel BR,
- Zhang J, et al.
- 13.↵
- Li AM,
- Ducker GS,
- Li Y,
- Seoane JA,
- Xiao Y,
- Melemenidis S, et al.
- 14.↵
- 15.↵
- Minn AJ,
- Gupta GP,
- Siegel PM,
- Bos PD,
- Shu W,
- Giri DD, et al.
- 16.↵
- Xiao Y,
- Thakkar KN,
- Zhao H,
- Broughton J,
- Li Y,
- Seoane JA, et al.
- 17.↵
- 18.↵
- Clarke C,
- Madden SF,
- Doolan P,
- Aherne ST,
- Joyce H,
- O’Driscoll L, et al.
- 19.↵
- Sabatier R,
- Finetti P,
- Adelaide J,
- Guille A,
- Borg JP,
- Chaffanet M, et al.
- 20.↵
- 21.↵
- 22.↵
- 23.↵
- Jiang H,
- Tiche SJ,
- He CJ,
- Liu J,
- Bian F,
- Jedoui M, et al.
- 24.↵
- Nikiforov MA,
- Chandriani S,
- O’Connell B,
- Petrenko O,
- Kotenko I,
- Beavis A, et al.
- 25.↵
- Haggerty TJ,
- Zeller KI,
- Osthus RC,
- Wonsey DR,
- Dang CV.
- 26.↵
- 27.↵
- 28.↵
- 29.↵
- 30.↵
- Ping XL,
- Sun BF,
- Wang L,
- Xiao W,
- Yang X,
- Wang WJ, et al.
- 31.↵
- 32.↵
- 33.
- 34.↵
- 35.↵
- 36.↵
- 37.↵
- 38.↵
- 39.↵
- 40.↵
- Zhao M,
- Zhang D,
- Jiang H,
- Kuganesan N,
- Natarajan S,
- Pu L, et al.
- 41.↵
- Zheng G,
- Dahl JA,
- Niu Y,
- Fedorcsak P,
- Huang CM,
- Li CJ, et al.
- 42.↵
- 43.↵
- Kundu A,
- Brinkley GJ,
- Nam H,
- Karki S,
- Kirkman R,
- Pandit M, et al.
- 44.↵
- 45.↵
- Kusi M,
- Zand M,
- Lin LL,
- Chen M,
- Lopez A,
- Lin CL, et al.
- 46.↵
- 47.↵
- 48.↵
- 49.↵
- 50.↵
- 51.↵
- 52.↵
- 53.↵
- 54.↵
- 55.↵
- 56.↵
- 57.↵
- Possemato R,
- Marks KM,
- Shaul YD,
- Pacold ME,
- Kim D,
- Birsoy K, et al.
- 58.
- 59.↵
- Ye J,
- Mancuso A,
- Tong X,
- Ward PS,
- Fan J,
- Rabinowitz JD, et al.
- 60.↵
- Kamphorst JJ,
- Nofal M,
- Commisso C,
- Hackett SR,
- Lu W,
- Grabocka E, et al.
- 61.↵
- 62.↵
- Jiang H,
- Jedoui M,
- Ye J.
- 63.↵
- 64.↵
- Jiang H,
- Li AM,
- Ye J.
- 65.↵
- 66.↵
- 67.↵
- 68.↵
- Schweizer MT,
- Haugk K,
- McKiernan JS,
- Gulati R,
- Cheng HH,
- Maes JL, et al.
- 69.↵
- Shah DP,
- Vancuylenburg CS,
- Olzomer EM,
- Chen SY,
- Grams RJ,
- Beretta M, et al.
- 70.↵
In this issue
Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin, Jiangbin Ye
Cancer Biology & Medicine Sep 2026, 23 (9) 1303-1319; DOI: 10.20892/j.issn.2095-3941.2025.0444
Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin, Jiangbin Ye
Cancer Biology & Medicine Sep 2026, 23 (9) 1303-1319; DOI: 10.20892/j.issn.2095-3941.2025.0444
Jump to section
Related Articles
- No related articles found.
Cited By...
- No citing articles found.






