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Research ArticleOriginal Article
Open Access

Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer

Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin and Jiangbin Ye
Cancer Biology & Medicine September 2026, 23 (9) 1303-1319; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0444
Xin Jin
1Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin 130000, China
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Albert M. Li
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
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Man Zhao
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Haowen Jiang
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Yiren Xiao
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Michaela Yip
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Stavros Melemenidis
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Scott Jackson
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Yanan Yang
4Agilent Technologies, Santa Clara, CA 95051, USA
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Cathyrin Simmermaker
4Agilent Technologies, Santa Clara, CA 95051, USA
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Meng-Ning Zhou
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
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Subarna Sinha
5Department of Computer Science, Stanford University, Stanford, CA 94305, USA
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Daniel J. Cuthbertson
4Agilent Technologies, Santa Clara, CA 95051, USA
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Erinn B. Rankin
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
6Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
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  • For correspondence: erankin{at}stanford.edu jiangbinye{at}muhn.edu.cn
Jiangbin Ye
2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
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  • For correspondence: erankin{at}stanford.edu jiangbinye{at}muhn.edu.cn
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Article Information

vol. 23 no. 9 1303-1319
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0444
PubMed 
41821182

Published By 
Cancer Biology & Medicine
History 
  • Received August 26, 2025
  • Accepted January 28, 2026
  • Published online September 22, 2026.

Article Versions

  • previous version (March 12, 2026 - 06:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Xin Jin1,2,
  2. Albert M. Li2,3,
  3. Man Zhao2,
  4. Haowen Jiang2,
  5. Yiren Xiao2,
  6. Michaela Yip2,
  7. Stavros Melemenidis2,
  8. Scott Jackson2,
  9. Yanan Yang4,
  10. Cathyrin Simmermaker4,
  11. Meng-Ning Zhou2,
  12. Subarna Sinha5,
  13. Daniel J. Cuthbertson4,
  14. Erinn B. Rankin2,3,6⇑ and
  15. Jiangbin Ye2,3⇑
  1. 1Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin 130000, China
  2. 2Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
  3. 3Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA
  4. 4Agilent Technologies, Santa Clara, CA 95051, USA
  5. 5Department of Computer Science, Stanford University, Stanford, CA 94305, USA
  6. 6Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
  1. Correspondence to: Erinn B. Rankin and Jiangbin Ye, E-mail: erankin{at}stanford.edu and jiangbinye{at}muhn.edu.cn
View Full Text

Funding

  • Stanford Maternal and Child Health Research Institute Faculty Scholar Award

    2020
  • American Cancer Society Research Scholar

    RSG-20–036–01
  • Agilent University Relations SIRA program

    #4792

This work was supported by the Stanford Maternal and Child Health Research Institute Faculty Scholar Award (2020), the American Cancer Society Research Scholar Grant (Grant No. RSG-20–036–01), and the Agilent University Relations SIRA program (Grant ID #4792) to J.Y.

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Cancer Biology & Medicine: 23 (9)
Cancer Biology & Medicine
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Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin, Jiangbin Ye
Cancer Biology & Medicine Sep 2026, 23 (9) 1303-1319; DOI: 10.20892/j.issn.2095-3941.2025.0444

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Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin, Jiangbin Ye
Cancer Biology & Medicine Sep 2026, 23 (9) 1303-1319; DOI: 10.20892/j.issn.2095-3941.2025.0444
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Keywords

  • Mitochondria uncoupler
  • serine catabolism
  • one-carbon unit metabolism
  • FTO
  • m6A
  • breast cancer
  • metastasis

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