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Circadian-driven transcriptional programs govern metastatic progression

Jie Wang, Hao Pan, Xuan Wang, Yuru Ren, Yiwen Huang, Yizhou Liu, Hejin Lai, Zhimin Fei, Ning Pu and Yu Wang
Cancer Biology & Medicine September 2026, 23 (9) 1213-1229; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0491
Jie Wang
1Department of Chinese Medicine & Integrative Medicine, Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University, Shanghai 201104, China
2Department of Chinese Medicine & Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai 200030, China
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Hao Pan
3Department of Neurosurgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Xuan Wang
4Endocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
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Yuru Ren
5Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Yiwen Huang
4Endocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
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Yizhou Liu
6Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Hejin Lai
7CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
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Zhimin Fei
3Department of Neurosurgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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  • ORCID record for Zhimin Fei
  • For correspondence: tommyfei{at}126.com npu15{at}fudan.edu.cn yummy0326{at}163.com
Ning Pu
8Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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  • ORCID record for Ning Pu
  • For correspondence: tommyfei{at}126.com npu15{at}fudan.edu.cn yummy0326{at}163.com
Yu Wang
6Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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  • For correspondence: tommyfei{at}126.com npu15{at}fudan.edu.cn yummy0326{at}163.com
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Article Information

vol. 23 no. 9 1213-1229
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0491
PubMed 
41968750

Published By 
Cancer Biology & Medicine
History 
  • Received September 2, 2025
  • Accepted February 25, 2026
  • Published online September 22, 2026.

Article Versions

  • previous version (April 10, 2026 - 07:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Jie Wang1,2,
  2. Hao Pan3,
  3. Xuan Wang4,
  4. Yuru Ren5,
  5. Yiwen Huang4,
  6. Yizhou Liu6,
  7. Hejin Lai7,
  8. Zhimin Fei3⇑,
  9. Ning Pu8⇑ and
  10. Yu Wang6⇑
  1. 1Department of Chinese Medicine & Integrative Medicine, Shanghai Geriatric Medical Center, Zhongshan Hospital, Fudan University, Shanghai 201104, China
  2. 2Department of Chinese Medicine & Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai 200030, China
  3. 3Department of Neurosurgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  4. 4Endocrinology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
  5. 5Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  6. 6Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  7. 7CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  8. 8Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  1. Correspondence to: Zhimin Fei, Ning Pu and Yu Wang, E-mail: tommyfei{at}126.com, npu15{at}fudan.edu.cn and yummy0326{at}163.com
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Funding

  • National Natural Science Foundation of China

    82405067
  • Shanghai Municipal Health Commission

    2019SY017
  • Shanghai Municipal Health Commission Scientific Research Project

    20254Y0181
  • Youth Development Program, Scientific Research Project of Shanghai Geriatric Medical Center

    YQ2025-007

This research was supported by the National Natural Science Foundation of China (Grant No. 82405067), the Shanghai Municipal Health Commission (Grant No. 2019SY017), the Shanghai Municipal Health Commission Scientific Research Project (Grant No. 20254Y0181), and the Youth Development Program, Scientific Research Project of Shanghai Geriatric Medical Center (Grant No. YQ2025-007).

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Cancer Biology & Medicine: 23 (9)
Cancer Biology & Medicine
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Circadian-driven transcriptional programs govern metastatic progression
Jie Wang, Hao Pan, Xuan Wang, Yuru Ren, Yiwen Huang, Yizhou Liu, Hejin Lai, Zhimin Fei, Ning Pu, Yu Wang
Cancer Biology & Medicine Sep 2026, 23 (9) 1213-1229; DOI: 10.20892/j.issn.2095-3941.2025.0491

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Circadian-driven transcriptional programs govern metastatic progression
Jie Wang, Hao Pan, Xuan Wang, Yuru Ren, Yiwen Huang, Yizhou Liu, Hejin Lai, Zhimin Fei, Ning Pu, Yu Wang
Cancer Biology & Medicine Sep 2026, 23 (9) 1213-1229; DOI: 10.20892/j.issn.2095-3941.2025.0491
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    • Abstract
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    • Clinical relevance between circadian disruption and tumor metastasis
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Keywords

  • Circadian clock
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