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LetterLetter
Open Access

Identification of immune reconstitution and hematopoiesis restoration by scRNA-seq in bone marrow of multiple myeloma patients treated with high-dose melphalan following auto-HSCT

Qian Li, Yaling Wang, Hongfeng Yuan, Qiaomei Cai, Lina Zhao, Li Lin, Shuang Gao, Lin Chen, Zhiying Zhang, Jing Ma, Su Liu, Zeng Cao, Haifeng Zhao, Yufei Wang, Shihui Li, Pan Lv, Huihui Zhang, Guowen Wang, Guang Yang, Xiaodong Zhang and Yafei Wang
Cancer Biology & Medicine February 2026, 23 (2) 247-251; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0585
Qian Li
1Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Yaling Wang
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Hongfeng Yuan
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Qiaomei Cai
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Lina Zhao
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Li Lin
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Shuang Gao
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Lin Chen
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Zhiying Zhang
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Jing Ma
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Su Liu
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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Zeng Cao
1Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Haifeng Zhao
1Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Yufei Wang
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Shihui Li
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Pan Lv
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Huihui Zhang
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Guowen Wang
4National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin’s Clinical Research Center for Cancer, Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: wangguowen{at}tmu.edu.cn yangguang{at}tjmuch.com zhangxiaodong{at}tjmuch.com yfwang{at}tmu.edu.cn
Guang Yang
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: wangguowen{at}tmu.edu.cn yangguang{at}tjmuch.com zhangxiaodong{at}tjmuch.com yfwang{at}tmu.edu.cn
Xiaodong Zhang
3State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: wangguowen{at}tmu.edu.cn yangguang{at}tjmuch.com zhangxiaodong{at}tjmuch.com yfwang{at}tmu.edu.cn
Yafei Wang
1Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
2Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
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  • ORCID record for Yafei Wang
  • For correspondence: wangguowen{at}tmu.edu.cn yangguang{at}tjmuch.com zhangxiaodong{at}tjmuch.com yfwang{at}tmu.edu.cn
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Article Information

vol. 23 no. 2 247-251
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0585
PubMed 
41766112

Published By 
Cancer Biology & Medicine
History 
  • Received November 10, 2025
  • Accepted January 8, 2026
  • Published online March 10, 2026.

Article Versions

  • previous version (February 27, 2026 - 20:47).
  • previous version (February 27, 2026 - 21:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    82270208 to Ya-fei Wang
  • National Natural Science Foundation of China

    82372818 to Xiao-dong Zhang
  • “Clinical-Basic” Co-Pl Program

    20250206
  • Tianjin Key Medical Discipline Construction Project

    TJYXZDXK-3-003A

This work was supported by the National Natural Science Foundation of China (Grant Nos. 82270208 to Ya-fei Wang and 82372818 to Xiao-dong Zhang) and was supported by the “Clinical-Basic” Co-Pl Program (Grant No. 20250206) of Tianjin Medical University Cancer Institute & Hospital. This work was funded by Tianjin Key Medical Discipline Construction Project (Grant No. TJYXZDXK-3-003A).

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Identification of immune reconstitution and hematopoiesis restoration by scRNA-seq in bone marrow of multiple myeloma patients treated with high-dose melphalan following auto-HSCT
Qian Li, Yaling Wang, Hongfeng Yuan, Qiaomei Cai, Lina Zhao, Li Lin, Shuang Gao, Lin Chen, Zhiying Zhang, Jing Ma, Su Liu, Zeng Cao, Haifeng Zhao, Yufei Wang, Shihui Li, Pan Lv, Huihui Zhang, Guowen Wang, Guang Yang, Xiaodong Zhang, Yafei Wang
Cancer Biology & Medicine Feb 2026, 23 (2) 247-251; DOI: 10.20892/j.issn.2095-3941.2025.0585

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Identification of immune reconstitution and hematopoiesis restoration by scRNA-seq in bone marrow of multiple myeloma patients treated with high-dose melphalan following auto-HSCT
Qian Li, Yaling Wang, Hongfeng Yuan, Qiaomei Cai, Lina Zhao, Li Lin, Shuang Gao, Lin Chen, Zhiying Zhang, Jing Ma, Su Liu, Zeng Cao, Haifeng Zhao, Yufei Wang, Shihui Li, Pan Lv, Huihui Zhang, Guowen Wang, Guang Yang, Xiaodong Zhang, Yafei Wang
Cancer Biology & Medicine Feb 2026, 23 (2) 247-251; DOI: 10.20892/j.issn.2095-3941.2025.0585
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