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Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers

Juanjuan Feng, Xuanzheng Xiao, Zhengke Lian, Ao Zhang and Xiufeng Pang
Cancer Biology & Medicine February 2026, 23 (2) 162-168; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0612
Juanjuan Feng
1Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China
2Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China
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Xuanzheng Xiao
3Shanghai Frontiers Science Center for Drug Target Identification and Delivery, State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China
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Zhengke Lian
1Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China
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Ao Zhang
3Shanghai Frontiers Science Center for Drug Target Identification and Delivery, State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China
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Xiufeng Pang
1Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China
4Chongqing Institute of East China Normal University, Chongqing 401120, China
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  • ORCID record for Xiufeng Pang
  • For correspondence: xfpang{at}bio.ecnu.edu.cn
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Article Information

vol. 23 no. 2 162-168
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2025.0612
PubMed 
41664305

Published By 
Cancer Biology & Medicine
History 
  • Received October 8, 2025
  • Accepted January 5, 2026
  • Published online March 10, 2026.

Article Versions

  • previous version (February 9, 2026 - 05:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2026, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

Funding

  • National Natural Science Foundation of China

    82472677
  • National Natural Science Foundation of China

    82404653
  • National Natural Science Foundation of China

    U25A20103
  • National Natural Science Foundation of China

    223B2704
  • Natural Science Foundation of Shanghai

    23ZR1418900
  • Natural Science Foundation of Chongqing

    CSTB2023NSCQ-MSX0367

This work was supported by the National Natural Science Foundation of China (Grant Nos. 82472677, 82404653, U25A20103, and 223B2704), the Natural Science Foundation of Shanghai (Grant No. 23ZR1418900), and the Natural Science Foundation of Chongqing (Grant No. CSTB2023NSCQ-MSX0367).

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Cancer Biology & Medicine: 23 (2)
Cancer Biology & Medicine
Vol. 23, Issue 2
15 Feb 2026
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Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers
Juanjuan Feng, Xuanzheng Xiao, Zhengke Lian, Ao Zhang, Xiufeng Pang
Cancer Biology & Medicine Feb 2026, 23 (2) 162-168; DOI: 10.20892/j.issn.2095-3941.2025.0612

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Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers
Juanjuan Feng, Xuanzheng Xiao, Zhengke Lian, Ao Zhang, Xiufeng Pang
Cancer Biology & Medicine Feb 2026, 23 (2) 162-168; DOI: 10.20892/j.issn.2095-3941.2025.0612
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    • Pan-KRAS inhibitors: broad-spectrum targeting beyond allele-specific therapies
    • KRAS molecular glues: beyond conventional inhibitors toward tri-complex strategies
    • Therapeutic KRAS degradation: navigating preclinical efficacy and clinical challenges for a new class of anticancer agents
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