Malignant ascites enhance γδ T cell cytotoxicity toward ovarian cancer via chemokine-mediated recruitment

Zhanqun Yang; Ying Liu; Mengzhu Zheng; Hui Li; Ruoyao Cui; Pan Wang; Tianhui He; Hongyan Guo; Yinglin Zhou; Jian Lin; Long Chen

doi:10.20892/j.issn.2095-3941.2025.0072

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Malignant ascites enhance γδ T cell cytotoxicity toward ovarian cancer via chemokine-mediated recruitment

Zhanqun Yang, Ying Liu, Mengzhu Zheng, Hui Li, Ruoyao Cui, Pan Wang, Tianhui He, Hongyan Guo, Yinglin Zhou, Jian Lin and Long Chen

Cancer Biology & Medicine June 2025, 22 (6) 639-643; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0072

Zhanqun Yang

1Department of Pharmacy, Peking University Third Hospital Cancer Center, Peking University Third Hospital, Beijing 100191, China

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Ying Liu

2Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

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Mengzhu Zheng

3Key Laboratory of Tropical Biological Resources of Ministry of Education, Song Li’s Academician Workstation of Hainan University, School of Pharmaceutical Sciences, Hainan University, Haikou 572000, China

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Hui Li

1Department of Pharmacy, Peking University Third Hospital Cancer Center, Peking University Third Hospital, Beijing 100191, China

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Ruoyao Cui

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Pan Wang

4Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China

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Tianhui He

4Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China

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Hongyan Guo

4Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China

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Yinglin Zhou

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Jian Lin

1Department of Pharmacy, Peking University Third Hospital Cancer Center, Peking University Third Hospital, Beijing 100191, China

5Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871, China

6College of Life Science, Anhui Medical University, Hefei 230032, China

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ORCID record for Jian Lin
For correspondence: linjian{at}pku.edu.cn lcchenlong{at}163.com

Long Chen

1Department of Pharmacy, Peking University Third Hospital Cancer Center, Peking University Third Hospital, Beijing 100191, China

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ORCID record for Long Chen
For correspondence: linjian{at}pku.edu.cn lcchenlong{at}163.com

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vol. 22 no. 6 639-643

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https://doi.org/10.20892/j.issn.2095-3941.2025.0072

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Cancer Biology & Medicine

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Received March 11, 2025
Accepted May 6, 2025
Published online July 9, 2025.

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previous version (June 6, 2025 - 03:17).
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National Natural Science Foundation of China
82274034
Peking University Medicine plus X Pilot Program-Platform Construction Project
2024YXXLHPT004

This work was supported by the National Natural Science Foundation of China (Grant No. 82274034) and the Peking University Medicine plus X Pilot Program-Platform Construction Project (Grant No. 2024YXXLHPT004).

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Malignant ascites enhance γδ T cell cytotoxicity toward ovarian cancer via chemokine-mediated recruitment

Zhanqun Yang, Ying Liu, Mengzhu Zheng, Hui Li, Ruoyao Cui, Pan Wang, Tianhui He, Hongyan Guo, Yinglin Zhou, Jian Lin, Long Chen

Cancer Biology & Medicine Jun 2025, 22 (6) 639-643; DOI: 10.20892/j.issn.2095-3941.2025.0072

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Malignant ascites enhance γδ T cell cytotoxicity toward ovarian cancer via chemokine-mediated recruitment

Zhanqun Yang, Ying Liu, Mengzhu Zheng, Hui Li, Ruoyao Cui, Pan Wang, Tianhui He, Hongyan Guo, Yinglin Zhou, Jian Lin, Long Chen

Cancer Biology & Medicine Jun 2025, 22 (6) 639-643; DOI: 10.20892/j.issn.2095-3941.2025.0072

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Malignant ascites enhance γδ T cell cytotoxicity toward ovarian cancer via chemokine-mediated recruitment

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