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Research ArticleOriginal Article
Open Access

Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis

Li Yuan, Yue Wang, Junjie Cheng, Shilin Lin, Aying Ma, Kunchao Li, Yiming Zheng, Zhaochong Zeng, Aiwu Ke, Chao Gao and Shisuo Du
Cancer Biology & Medicine April 2025, 22 (4) 396-411; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0544
Li Yuan
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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Yue Wang
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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Junjie Cheng
2Graduate School of Bengbu Medical University, Bengbu 233030, China
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Shilin Lin
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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Aying Ma
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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Kunchao Li
3Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
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Yiming Zheng
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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Zhaochong Zeng
4Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Aiwu Ke
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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  • For correspondence: [email protected] [email protected] [email protected]
Chao Gao
1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
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  • For correspondence: [email protected] [email protected] [email protected]
Shisuo Du
4Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Cancer Biology & Medicine: 22 (4)
Cancer Biology & Medicine
Vol. 22, Issue 4
15 Apr 2025
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Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis
Li Yuan, Yue Wang, Junjie Cheng, Shilin Lin, Aying Ma, Kunchao Li, Yiming Zheng, Zhaochong Zeng, Aiwu Ke, Chao Gao, Shisuo Du
Cancer Biology & Medicine Apr 2025, 22 (4) 396-411; DOI: 10.20892/j.issn.2095-3941.2024.0544

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Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis
Li Yuan, Yue Wang, Junjie Cheng, Shilin Lin, Aying Ma, Kunchao Li, Yiming Zheng, Zhaochong Zeng, Aiwu Ke, Chao Gao, Shisuo Du
Cancer Biology & Medicine Apr 2025, 22 (4) 396-411; DOI: 10.20892/j.issn.2095-3941.2024.0544
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Keywords

  • circTMEM56
  • hepatocellular carcinoma
  • cGAS-STING
  • radiotherapy
  • dendritic cell

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