Research ArticleOriginal Article
Open Access

Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis

Li Yuan, Yue Wang, Junjie Cheng, Shilin Lin, Aying Ma, Kunchao Li, Yiming Zheng, Zhaochong Zeng, Aiwu Ke, Chao Gao and Shisuo Du
Cancer Biology & Medicine April 2025, 22 (4) 396-411; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0544

Article Information

vol. 22 no. 4 396-411
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2024.0544
PubMed 
40269559
Published By 
Cancer Biology & Medicine
History 
  • Received November 22, 2024
  • Accepted February 26, 2025
  • Published online April 26, 2025.

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Copyright & Usage 
Copyright: © 2025, The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Li Yuan1,*,
  2. Yue Wang1,*,
  3. Junjie Cheng2,*,
  4. Shilin Lin1,
  5. Aying Ma1,
  6. Kunchao Li3,
  7. Yiming Zheng1,
  8. Zhaochong Zeng4,
  9. Aiwu Ke1⇑,
  10. Chao Gao1⇑ and
  11. Shisuo Du4⇑
  1. 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China
  2. 2Graduate School of Bengbu Medical University, Bengbu 233030, China
  3. 3Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
  4. 4Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  1. Correspondence to: Aiwu Ke, Chao Gao and Shisuo Du, E-mail: keaiwu_fd{at}hotmail.com, gachao_4068{at}163.com and du.shisuo{at}zs-hospital.sh.cn
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Funding

  • National Key Research and Development Program of China

    2023YFC3402700

  • Shanghai Municipal Natural Science Foundation

    22ZR1411200

  • China Postdoctoral Science Fund-General Fund

    2022M720779

  • Zhongshan Hospital Affiliated to Shanghai Fudan University for Young Scientists

    2023ZSQN26

  • National Natural Science Foundation of China

    82403999

  • National Natural Science Foundation of China

    82073479

This study was funded by the National Key Research and Development Program of China (Grant No. 2023YFC3402700), Shanghai Municipal Natural Science Foundation (Grant No. 22ZR1411200), China Postdoctoral Science Fund-General Fund (Grant No. 2022M720779), Research Fund of Zhongshan Hospital Affiliated to Shanghai Fudan University for Young Scientists (Grant No. 2023ZSQN26), and National Natural Science Foundation of China (Grant Nos. 82403999 and 82073479).

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