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LetterLetter
Open Access

Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy

Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang and Guoren Zhou
Cancer Biology & Medicine December 2025, 22 (12) 1544-1552; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0393
Shuyi Hu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Zipeng Wu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Yingying Dai
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Xinhong Shi
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Qin Hu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Caolu Liu
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Yifei Zhu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Ruofan Yu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Jingwen Li
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Ying Liu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Tianyi Liu
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Lin Lu
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Chengyun Yao
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Bo Shen
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Meiqi Shi
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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Cheng Chen
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
3Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010020, China
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  • For correspondence: zhouguoren888{at}163.com wangxiaohua{at}jszlyy.com.cn njmudoctor{at}163.com
Xiaohua Wang
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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  • For correspondence: zhouguoren888{at}163.com wangxiaohua{at}jszlyy.com.cn njmudoctor{at}163.com
Guoren Zhou
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
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  • ORCID record for Guoren Zhou
  • For correspondence: zhouguoren888{at}163.com wangxiaohua{at}jszlyy.com.cn njmudoctor{at}163.com
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References

  1. 1.↵
    1. Planchard D,
    2. Feng PH,
    3. Karaseva N,
    4. Kim SW,
    5. Kim TM,
    6. Lee CK, et al.
    Osimertinib plus platinum-pemetrexed in newly diagnosed epidermal growth factor receptor mutation-positive advanced/metastatic non-small-cell lung cancer: safety run-in results from the FLAURA2 study. ESMO Open. 2021; 6: 100271.
  2. 2.↵
    1. Qin BD,
    2. Jiao XD,
    3. Yuan LY,
    4. Wu Y,
    5. Ling Y,
    6. Zang YS.
    Immunotherapy-based regimens for patients with EGFR-mutated non-small cell lung cancer who progressed on EGFR-TKI therapy. J Immunother Cancer. 2024; 12: e008818.
  3. 3.↵
    1. Borcoman E,
    2. Kanjanapan Y,
    3. Champiat S,
    4. Kato S,
    5. Servois V,
    6. Kurzrock R, et al.
    Novel patterns of response under immunotherapy. Ann Oncol. 2019; 30: 385–96.
    OpenUrlCrossRefPubMed
  4. 4.
    1. Gandara DR,
    2. von Pawel J,
    3. Mazieres J,
    4. Sullivan R,
    5. Helland Å,
    6. Han JY, et al.
    Atezolizumab treatment beyond progression in advanced NSCLC: results from the randomized, phase III OAK study. J Thorac Oncol. 2018; 13: 1906–18.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Gang X,
    2. Yan J,
    3. Li X,
    4. Shi S,
    5. Xu L,
    6. Liu R, et al.
    Immune checkpoint inhibitors rechallenge in non-small cell lung cancer: current evidence and future directions. Cancer Lett. 2024; 604: 217241.
  6. 6.↵
    1. Wang Z,
    2. Wei L,
    3. Li J,
    4. Zhou H,
    5. Li S,
    6. Chen D, et al.
    Combing stereotactic body radiotherapy with checkpoint inhibitors after oligoprogression in advanced non-small cell lung cancer. Transl Lung Cancer Res. 2021; 10: 4368–79.
    OpenUrlPubMed
  7. 7.↵
    1. Reckamp KL,
    2. Redman MW,
    3. Dragnev KH,
    4. Minichiello K,
    5. Villaruz LC,
    6. Faller B, et al.
    Phase II randomized study of ramucirumab and pembrolizumab versus standard of care in advanced non-small-cell lung cancer previously treated with immunotherapy-lung-MAP S1800A. J Clin Oncol. 2022; 40: 2295–306.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Lin G,
    2. Wang Z,
    3. Chu Q,
    4. Hu Y,
    5. Huang D,
    6. Wang J, et al.
    Rechallenge of immune checkpoint inhibitors in advanced non-small cell lung cancer. Thorac Cancer. 2024; 15: 419–26.
    OpenUrlPubMed
  9. 9.↵
    1. Feng Y,
    2. Tao Y,
    3. Chen H,
    4. Zhou Y,
    5. Tang L,
    6. Liu C, et al.
    Efficacy and safety of immune checkpoint inhibitor rechallenge in non-small cell lung cancer: a systematic review and meta-analysis. Thorac Cancer. 2023; 14: 2536–47.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Saal J,
    2. Eckstein M,
    3. Ritter M,
    4. Brossart P,
    5. Luetkens J,
    6. Ellinger J, et al.
    Dissection of progressive disease patterns for a modified classification for immunotherapy. JAMA Oncol. 2025; 11: 154–61.
    OpenUrlPubMed
  11. 11.↵
    1. Al Bakir M,
    2. Reading JL,
    3. Gamble S,
    4. Rosenthal R,
    5. Uddin I,
    6. Rowan A, et al.
    Clonal driver neoantigen loss under EGFR TKI and immune selection pressures. Nature. 2025; 639: 1052–9.
    OpenUrlPubMed
  12. 12.↵
    1. Syn NL,
    2. Teng MWL,
    3. Mok TSK,
    4. Soo RA.
    De-novo and acquired resistance to immune checkpoint targeting. Lancet Oncol. 2017; 18: e731–41.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Herbst RS,
    2. Garon EB,
    3. Kim DW,
    4. Cho BC,
    5. Perez-Gracia JL,
    6. Han JY, et al.
    Long-term outcomes and retreatment among patients with previously treated, programmed death-ligand 1-positive, advanced non-small-cell lung cancer in the KEYNOTE-010 study. J Clin Oncol. 2020; 38: 1580–90.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Gettinger SN,
    2. Wurtz A,
    3. Goldberg SB,
    4. Rimm D,
    5. Schalper K,
    6. Kaech S, et al.
    Clinical features and management of acquired resistance to PD-1 axis inhibitors in 26 patients with advanced non-small cell lung cancer. J Thorac Oncol. 2018; 13: 831–9.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Kitagawa S,
    2. Hakozaki T,
    3. Kitadai R,
    4. Hosomi Y.
    Switching administration of anti-PD-1 and anti-PD-L1 antibodies as immune checkpoint inhibitor rechallenge in individuals with advanced non-small cell lung cancer: case series and literature review. Thorac Cancer. 2020; 11: 1927–33.
    OpenUrlPubMed
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Cancer Biology & Medicine: 22 (12)
Cancer Biology & Medicine
Vol. 22, Issue 12
15 Dec 2025
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Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy
Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang, Guoren Zhou
Cancer Biology & Medicine Dec 2025, 22 (12) 1544-1552; DOI: 10.20892/j.issn.2095-3941.2025.0393

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Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy
Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang, Guoren Zhou
Cancer Biology & Medicine Dec 2025, 22 (12) 1544-1552; DOI: 10.20892/j.issn.2095-3941.2025.0393
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