LetterLetter
Open Access
Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy
Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang and Guoren Zhou
Cancer Biology & Medicine December 2025, 22 (12) 1544-1552; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0393
Shuyi Hu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Zipeng Wu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Yingying Dai
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Xinhong Shi
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Qin Hu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Caolu Liu
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Yifei Zhu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Ruofan Yu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Jingwen Li
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Ying Liu
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Tianyi Liu
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Lin Lu
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Chengyun Yao
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Bo Shen
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Meiqi Shi
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Cheng Chen
2Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
3Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010020, China
Xiaohua Wang
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China
Guoren Zhou
1Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China

References
- 1.↵
- Planchard D,
- Feng PH,
- Karaseva N,
- Kim SW,
- Kim TM,
- Lee CK, et al.
- 2.↵
- Qin BD,
- Jiao XD,
- Yuan LY,
- Wu Y,
- Ling Y,
- Zang YS.
- 3.↵
- 4.
- 5.↵
- Gang X,
- Yan J,
- Li X,
- Shi S,
- Xu L,
- Liu R, et al.
- 6.↵
- 7.↵
- Reckamp KL,
- Redman MW,
- Dragnev KH,
- Minichiello K,
- Villaruz LC,
- Faller B, et al.
- 8.↵
- 9.↵
- 10.↵
- 11.↵
- 12.↵
- 13.↵
- 14.↵
- 15.↵
In this issue
Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy
Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang, Guoren Zhou
Cancer Biology & Medicine Dec 2025, 22 (12) 1544-1552; DOI: 10.20892/j.issn.2095-3941.2025.0393
Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy
Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang, Guoren Zhou
Cancer Biology & Medicine Dec 2025, 22 (12) 1544-1552; DOI: 10.20892/j.issn.2095-3941.2025.0393
Jump to section
Related Articles
- No related articles found.
Cited By...
- No citing articles found.






