Cancer Biology & Medicine: 22 (12)

December 15, 2025; Volume 22,Issue 12

Editorial

Open Access
Harnessing the STING pathway for HCC treatment
Carmen Chak-Lui Wong, Cerise Yuen-Ki Chan, Helen Do-Gai Xue and Chun-Ming Wong

Cancer Biology & Medicine December 2025, 22 (12) 1423-1430; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0434

Perspective

Open Access
From bone marrow to the tumor microenvironment: how neutrophil maturation shapes cancer immunity
Tao Shi, Yiran Cai, Hanbing Wang and Jia Wei

Cancer Biology & Medicine December 2025, 22 (12) 1431-1438; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0547

Reviews

Open Access
Current status of traditional Chinese medicine in modulating mitochondrial metabolic abnormalities in tumors
Siyi Ma, Jiarong Li, Bingjie Hao and Lihong Fan

Cancer Biology & Medicine December 2025, 22 (12) 1439-1454; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0246
Open Access
Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications
Miaomiao Zheng, Jun Zhou and Yijie Wang

Cancer Biology & Medicine December 2025, 22 (12) 1455-1472; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0340
Open Access
Harnessing the power of cancer-associated fibroblasts to revolutionize pancreatic cancer treatment
Jian Shen, Ruopu Wu, Tao Yin, Qun Wang and Lei Nie

Cancer Biology & Medicine December 2025, 22 (12) 1473-1492; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0288
Open Access
From residual risk to precision intervention: the evolving role of minimal residual disease in breast cancer management
Junnan Xu, Kun Fang, Xiaoxi Li, Li Han, Shulan Sun and Tao Sun

Cancer Biology & Medicine December 2025, 22 (12) 1493-1514; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0431
Open Access
Current status of management of immune-related adverse events and practical needs for oncologist education
Binhe Tian, Yuanmei Yang, Shuman Kuang, Mingjian Piao, Chengjie Li, Haitao Zhao and Hanping Wang

Cancer Biology & Medicine December 2025, 22 (12) 1515-1536; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0346

Letters

Open Access
COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1⁺CD8⁺ T cell infiltration in NSCLC
Lin Ma, Menglin Bai, Yao Wang, Xueying Zhai, Jinming Yu and Xiangjiao Meng

Cancer Biology & Medicine December 2025, 22 (12) 1537-1543; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0205
Open Access
Immunotherapy rechallenge of patients with advanced NSCLC progression after sequential treatment with third-generation EGFR-TKI and immunotherapy
Shuyi Hu, Zipeng Wu, Yingying Dai, Xinhong Shi, Qin Hu, Caolu Liu, Yifei Zhu, Ruofan Yu, Jingwen Li, Ying Liu, Tianyi Liu, Lin Lu, Chengyun Yao, Bo Shen, Meiqi Shi, Cheng Chen, Xiaohua Wang and Guoren Zhou

Cancer Biology & Medicine December 2025, 22 (12) 1544-1552; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0393
Open Access
Effectiveness of postoperative adjuvant radiochemotherapy versus radiotherapy in thoracic esophageal squamous cell carcinoma with lymph node metastasis: a multicenter randomized study
Jiangfeng Wang, Wenhui Shen, Xiaojiang Sun, Ding Wang, Youhua Jiang and Weimin Mao

Cancer Biology & Medicine December 2025, 22 (12) 1553-1557; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0479

Original Articles

Open Access
CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway
Chao Xu, Zekun Li, Yueying Shan, Chunhua She, Yanfang Yang, Tianxing Zhou, Yongjie Xie, Bo Ni, Chenyang Meng, Guangcong Shen, Boyang Fu, Guannan Sheng, Liangliang Wu, Jinlong Pei, Tiansuo Zhao, Song Gao, Hongwei Wang, Chengqi Deng, Kaiyuan Wang, Antao Chang, Chongbiao Huang, Lei Shi, Shengyu Yang, Jun Yu, Jihui Hao and Xiuchao Wang

Cancer Biology & Medicine December 2025, 22 (12) 1558-1577; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0058
Open Access
Chidamide suppresses macrophage-mediated immune evasion and tumor progression in small cell lung cancer by targeting the STAT4/CCL2 signaling pathway
Wenting Liu, Ting Mei, Yantao Jiang, Jingya Wang, Mengjie Li, Liuchun Wang, Zhaoting Meng, Tingting Qin and Dingzhi Huang

Cancer Biology & Medicine December 2025, 22 (12) 1578-1604; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0241
Open Access
Comprehensive investigation of the molecular basis of cancer dependencies suggests therapeutic options for breast cancer
Rui Ding, Zhiming Shao and Tianjian Yu

Cancer Biology & Medicine December 2025, 22 (12) 1605-1626; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0290
Open Access
Nintedanib enhances tumor cell radiosensitivity by promoting ferroptosis and modulating the ATF4/SLC7A11/GSH axis
Chunya Li, Aifeina Aili, Qingqing Yu, Mu Yang, Qiyuan Feng, Duo Xu, Bo Liu, Jingyao Tu and Xianglin Yuan

Cancer Biology & Medicine December 2025, 22 (12) 1627-1647; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0275

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