Epigenetic regulators as the foundation for molecular classification of colorectal cancer

References

1. 1.↵
   2. Bray F,
   3. Laversanne M,
   4. Sung H,
   5. Ferlay J,
   6. Siegel RL,
   7. Soerjomataram I, et al.

   Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74: 229–63.

   OpenUrlCrossRefPubMed
2. 2.↵
   The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012; 487: 330–7.

   OpenUrlCrossRefPubMedWeb of Science
3. 3.↵
   2. Guinney J,
   3. Dienstmann R,
   4. Wang X,
   5. de Reyniès A,
   6. Schlicker A,
   7. Soneson C, et al.

   The consensus molecular subtypes of colorectal cancer. Nat Med. 2015; 21: 1350–6.

   OpenUrlCrossRefPubMed
4. 4.↵
   2. Toyota M,
   3. Ahuja N,
   4. Ohe-Toyota M,
   5. Herman JG,
   6. Baylin SB,
   7. Issa J-PJ.

   CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A. 1999; 96: 8681–6.

   OpenUrlAbstract/FREE Full Text
5. 5.↵
   2. Flavahan WA,
   3. Gaskell E,
   4. Bernstein BE.

   Epigenetic plasticity and the hallmarks of cancer. Science. 2017; 357: eaal2380.
6. 6.↵
   2. Joanito I,
   3. Wirapati P,
   4. Zhao N,
   5. Nawaz Z,
   6. Yeo G,
   7. Lee F, et al.

   Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat Genet. 2022; 54: 963–75.

   OpenUrlCrossRefPubMed
7. 7.↵
   2. Hanahan D.

   Hallmarks of cancer: new dimensions. Cancer Discov. 2022; 12: 31–46.

   OpenUrlAbstract/FREE Full Text
8. 8.↵
   2. Weisenberger DJ,
   3. Siegmund KD,
   4. Campan M,
   5. Young J,
   6. Long TI,
   7. Faasse MA, et al.

   CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006; 38: 787–93.

   OpenUrlCrossRefPubMedWeb of Science
9. 9.↵
   2. Ogino S,
   3. Nosho K,
   4. Kirkner GJ,
   5. Kawasaki T,
   6. Meyerhardt JA,
   7. Loda M, et al.

   CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut. 2009; 58: 90–6.

   OpenUrlAbstract/FREE Full Text
10. 10.↵
    2. Liu Z,
    3. Hu Y,
    4. Xie H,
    5. Chen K,
    6. Wen L,
    7. Fu W, et al.

    Single-cell chromatin accessibility analysis reveals the epigenetic basis and signature transcription factors for the molecular subtypes of colorectal cancers. Cancer Discov. 2024; 14: 1082–105.

    OpenUrl
11. 11.↵
    2. Dienstmann R,
    3. Vermeulen L,
    4. Guinney J,
    5. Kopetz S,
    6. Tejpar S,
    7. Tabernero J.

    Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 2017; 17: 79–92.

    OpenUrlPubMed
12. 12.↵
    2. Marusyk A,
    3. Janiszewska M,
    4. Polyak K.

    Intratumor heterogeneity: the rosetta stone of therapy resistance. Cancer Cell. 2020; 37: 471–84.

    OpenUrlCrossRefPubMed
13. 13.↵
    2. Bian S,
    3. Hou Y,
    4. Zhou X,
    5. Li X,
    6. Yong J,
    7. Wang Y, et al.

    Single-cell multiomics sequencing and analyses of human colorectal cancer. Science. 2018; 362: 1060–3.

    OpenUrlAbstract/FREE Full Text
14. 14.↵
    2. Li D,
    3. Bai Y,
    4. Feng Z,
    5. Li W,
    6. Yang C,
    7. Guo Y, et al.

    Study of promoter methylation patterns of HOXA2, HOXA5, and HOXA6 and its clinicopathological characteristics in colorectal cancer. Front Oncol. 2019; 9: 394.

    OpenUrl
15. 15.↵
    2. Gaudet F,
    3. Hodgson JG,
    4. Eden A,
    5. Jackson-Grusby L,
    6. Dausman J,
    7. Gray JW, et al.

    Induction of tumors in mice by genomic hypomethylation. Science. 2003; 300: 489–92.

    OpenUrlAbstract/FREE Full Text
16. 16.↵
    2. Bushweller JH.

    Targeting transcription factors in cancer — from undruggable to reality. Nat Rev Cancer. 2019; 19: 611–24.

    OpenUrl