Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
EditorialEditorial
Open Access

Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies

Hanhao Zheng, Daiyin Liu, Zhicong Liu, Mingjie An, Yuming Luo, Changhao Chen and Tianxin Lin
Cancer Biology & Medicine June 2024, 21 (6) 445-450; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0138
Hanhao Zheng
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daiyin Liu
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhicong Liu
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mingjie An
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuming Luo
3Department of General Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Changhao Chen
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Changhao Chen
  • For correspondence: chenchh53{at}mail.sysu.edu.cn lintx{at}mail.sysu.edu.cn
Tianxin Lin
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tianxin Lin
  • For correspondence: chenchh53{at}mail.sysu.edu.cn lintx{at}mail.sysu.edu.cn
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Reticker-Flynn NE,
    2. Zhang W,
    3. Belk JA,
    4. Basto PA,
    5. Escalante NK,
    6. Pilarowski GOW, et al.
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022; 185: 1924–42.e23.
    OpenUrlCrossRef
  2. 2.↵
    1. Quail DF,
    2. Joyce JA.
    Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013; 19: 1423–37.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Kobayashi H,
    2. Gieniec KA,
    3. Lannagan TRM,
    4. Wang T,
    5. Asai N,
    6. Mizutani Y, et al.
    The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis. Gastroenterology. 2022; 162: 890–906.
    OpenUrlCrossRef
  4. 4.↵
    1. Zheng H,
    2. An M,
    3. Luo Y,
    4. Diao X,
    5. Zhong W,
    6. Pang M, et al.
    PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. Cancer Cell. 2024; 42: 682–700.e12.
    OpenUrl
  5. 5.↵
    1. Labernadie A,
    2. Kato T,
    3. Brugues A,
    4. Serra-Picamal X,
    5. Derzsi S,
    6. Arwert E, et al.
    A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Nat Cell Biol. 2017; 19: 224–37.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Yang F,
    2. Wei Y,
    3. Han D,
    4. Li Y,
    5. Shi S,
    6. Jiao D, et al.
    Interaction with CD68 and regulation of GAS6 expression by endosialin in fibroblasts drives recruitment and polarization of macrophages in hepatocellular carcinoma. Cancer Res. 2020; 80: 3892–905.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Li Y,
    2. Zheng H,
    3. Luo Y,
    4. Lin Y,
    5. An M,
    6. Kong Y, et al.
    An HGF-dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis. Cancer Commun (Lond). 2023; 43: 1289–311.
    OpenUrl
  8. 8.↵
    1. Cadamuro M,
    2. Brivio S,
    3. Mertens J,
    4. Vismara M,
    5. Moncsek A,
    6. Milani C, et al.
    Platelet-derived growth factor-d enables liver myofibroblasts to promote tumor lymphangiogenesis in cholangiocarcinoma. J Hepatol. 2019; 70: 700–9.
    OpenUrl
  9. 9.↵
    1. Pelon F,
    2. Bourachot B,
    3. Kieffer Y,
    4. Magagna I,
    5. Mermet-Meillon F,
    6. Bonnet I, et al.
    Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms. Nat Commun. 2020; 11: 404.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Zhang R,
    2. Qi F,
    3. Shao S,
    4. Li G,
    5. Feng Y.
    Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF. Cancer Cell Int. 2019; 19: 192.
    OpenUrlCrossRef
  11. 11.↵
    1. Kim HJ,
    2. Yang K,
    3. Kim K,
    4. Lee YJ,
    5. Lee S,
    6. Ahn SY, et al.
    Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling. Cell Mol Immunol. 2022; 19: 1373–91.
    OpenUrl
  12. 12.↵
    1. Affo S,
    2. Nair A,
    3. Brundu F,
    4. Ravichandra A,
    5. Bhattacharjee S,
    6. Matsuda M, et al.
    Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021; 39: 866–82.e11.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Yu D,
    2. Li Y,
    3. Wang M,
    4. Gu J,
    5. Xu W,
    6. Cai H, et al.
    Exosomes as a new frontier of cancer liquid biopsy. Mol Cancer. 2022; 21: 56.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Chen C,
    2. Yang C,
    3. Tian X,
    4. Liang Y,
    5. Wang S,
    6. Wang X, et al.
    Downregulation of miR-100-5p in cancer-associated fibroblast-derived exosomes facilitates lymphangiogenesis in esophageal squamous cell carcinoma. Cancer Med. 2023; 12: 14468–83.
    OpenUrl
  15. 15.↵
    1. Zhang H,
    2. Deng T,
    3. Liu R,
    4. Ning T,
    5. Yang H,
    6. Liu D, et al.
    CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020; 19: 43.
    OpenUrlPubMed
  16. 16.↵
    1. Shi L,
    2. Zhu W,
    3. Huang Y,
    4. Zhuo L,
    5. Wang S,
    6. Chen S, et al.
    Cancer-associated fibroblast-derived exosomal microRNA-20a suppresses the PTEN/PI3K-AKT pathway to promote the progression and chemoresistance of non-small cell lung cancer. Clin Transl Med. 2022; 12: e989.
  17. 17.↵
    1. Liu X,
    2. Li J,
    3. Yang X,
    4. Li X,
    5. Kong J,
    6. Qi D, et al.
    Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling. Int J Oral Sci. 2023; 15: 32.
    OpenUrl
  18. 18.↵
    1. Liu C,
    2. Li M,
    3. Dong ZX,
    4. Jiang D,
    5. Li X,
    6. Lin S, et al.
    Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells. Acta Biomater. 2021; 131: 326–40.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Feig C,
    2. Jones JO,
    3. Kraman M,
    4. Wells RJ,
    5. Deonarine A,
    6. Chan DS, et al.
    Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-Pd-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A. 2013; 110: 20212–7.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Kalluri R.
    The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016; 16: 582–98.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Cancer Biology & Medicine: 21 (6)
Cancer Biology & Medicine
Vol. 21, Issue 6
15 Jun 2024
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Cancer Biology & Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies
(Your Name) has sent you a message from Cancer Biology & Medicine
(Your Name) thought you would like to see the Cancer Biology & Medicine web site.
Citation Tools
Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies
Hanhao Zheng, Daiyin Liu, Zhicong Liu, Mingjie An, Yuming Luo, Changhao Chen, Tianxin Lin
Cancer Biology & Medicine Jun 2024, 21 (6) 445-450; DOI: 10.20892/j.issn.2095-3941.2024.0138

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies
Hanhao Zheng, Daiyin Liu, Zhicong Liu, Mingjie An, Yuming Luo, Changhao Chen, Tianxin Lin
Cancer Biology & Medicine Jun 2024, 21 (6) 445-450; DOI: 10.20892/j.issn.2095-3941.2024.0138
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Roles of CAF subsets in shaping the lymphatic metastatic landscape through physical interactions
    • Roles of CAF subsets in shaping the lymphatic metastatic landscape through paracrine signaling
    • Roles of CAF subsets in shaping the lymphatic metastatic landscape through exosome secretion
    • Treatment applications of targeting CAF subsets
    • Conclusions and future perspectives
    • Conflict of interest statement
    • Author contributions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells
  • Google Scholar

More in this TOC Section

  • Multi-cancer early detection: from promise to practice and the next frontier
  • Tumor microenvironment-responsive polymeric nanoparticles for enhanced immunotherapy
  • Harnessing the STING pathway for HCC treatment
Show more Editorial

Similar Articles

Navigate

  • Home
  • Current Issue

More Information

  • About CBM
  • About CACA
  • About TMUCIH
  • Editorial Board
  • Subscription

For Authors

  • Instructions for authors
  • Journal Policies
  • Submit a Manuscript

Journal Services

  • Email Alerts
  • Facebook
  • RSS Feeds
  • Twitter

 

© 2026 Cancer Biology & Medicine

Powered by HighWire