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EditorialEditorial
Open Access

Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies

Hanhao Zheng, Daiyin Liu, Zhicong Liu, Mingjie An, Yuming Luo, Changhao Chen and Tianxin Lin
Cancer Biology & Medicine June 2024, 21 (6) 445-450; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0138
Hanhao Zheng
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
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Daiyin Liu
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
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Zhicong Liu
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
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Mingjie An
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
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Yuming Luo
3Department of General Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510003, China
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Changhao Chen
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
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  • ORCID record for Changhao Chen
  • For correspondence: chenchh53{at}mail.sysu.edu.cn lintx{at}mail.sysu.edu.cn
Tianxin Lin
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510003, China
2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, State Key Laboratory of Oncology in South China, Guangzhou 510003, China
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  • ORCID record for Tianxin Lin
  • For correspondence: chenchh53{at}mail.sysu.edu.cn lintx{at}mail.sysu.edu.cn
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    Figure 1

    Roles of CAFs in shaping the lymphatic metastatic landscape. Schematic illustration of various mechanisms through which CAF subsets shape the lymphatic metastatic landscape, including the physical interactions between CAF subsets and stromal cells, the stimulation of paracrine signaling via various cytokines, and the secretion of exosomes containing functional biological molecules.

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Cancer Biology & Medicine: 21 (6)
Cancer Biology & Medicine
Vol. 21, Issue 6
15 Jun 2024
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Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies
Hanhao Zheng, Daiyin Liu, Zhicong Liu, Mingjie An, Yuming Luo, Changhao Chen, Tianxin Lin
Cancer Biology & Medicine Jun 2024, 21 (6) 445-450; DOI: 10.20892/j.issn.2095-3941.2024.0138

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Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape: new insights and therapeutic strategies
Hanhao Zheng, Daiyin Liu, Zhicong Liu, Mingjie An, Yuming Luo, Changhao Chen, Tianxin Lin
Cancer Biology & Medicine Jun 2024, 21 (6) 445-450; DOI: 10.20892/j.issn.2095-3941.2024.0138
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  • Article
    • Roles of CAF subsets in shaping the lymphatic metastatic landscape through physical interactions
    • Roles of CAF subsets in shaping the lymphatic metastatic landscape through paracrine signaling
    • Roles of CAF subsets in shaping the lymphatic metastatic landscape through exosome secretion
    • Treatment applications of targeting CAF subsets
    • Conclusions and future perspectives
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