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Research ArticleOriginal Article
Open Access

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase II trial

Shuzhen Lai, Peijing Li, Xiaohui Liu, Guihong Liu, Tieming Xie, Xing Zhang, Xiaoxuan Wang, Jing Huang, Yiqiang Tang, Zhigang Liu, Guoping Shen, Chaoming Li, Fangxiao Lu, Lei Wang, Fagui Jiang, Caixing Sun, Yuanyuan Chen and Ming Chen
Cancer Biology & Medicine May 2024, 21 (5) 433-444; DOI: https://doi.org/10.20892/j.issn.2095-3941.2023.0373
Shuzhen Lai
1Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China
2Department of Radiation Oncology, Yuebei People’s Hospital Affiliated to the Medical College of Shantou University, Shaoguan 512026, China
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Peijing Li
3Department of Radiation Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences [Zhejiang Cancer Hospital Institute of Basic Medicine and Cancer (IBMC)], Chinese Academy of Sciences, Hangzhou 310022, China
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Xiaohui Liu
4Department of Radiation Oncology, The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 311403, China
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Guihong Liu
5Department of Radiation Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China
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Tieming Xie
6Department of Radiology, The Cancer Hospital of the University of Chinese Academy of Sciences [Zhejiang Cancer Hospital Institute of Basic Medicine and Cancer (IBMC)], Chinese Academy of Sciences, Hangzhou 310022, China
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Xing Zhang
7State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing 210000, China
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Xiaoxuan Wang
7State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing 210000, China
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Jing Huang
8Department of Radiation Oncology, The Affiliated Huai’an First People’s Hospital of Nanjing Medical University, Huai’an 223399, China
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Yiqiang Tang
9Department of Radiation Oncology, Jiangxi Cancer Hospital of Nanchang University, Nanchang 330029, China
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Zhigang Liu
10Department of Radiotherapy, Dongguan Institute of Clinical Cancer Research, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523059, China
11The Cancer Center, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, China
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Guoping Shen
12Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
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Chaoming Li
13Department of Oncology, Maoming People’s Hospital, Maoming 525000, China
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Fangxiao Lu
6Department of Radiology, The Cancer Hospital of the University of Chinese Academy of Sciences [Zhejiang Cancer Hospital Institute of Basic Medicine and Cancer (IBMC)], Chinese Academy of Sciences, Hangzhou 310022, China
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Lei Wang
3Department of Radiation Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences [Zhejiang Cancer Hospital Institute of Basic Medicine and Cancer (IBMC)], Chinese Academy of Sciences, Hangzhou 310022, China
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Fagui Jiang
14Department of Radiation Oncology, Kecheng District People’s Hospital, Quzhou 324003, China
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Caixing Sun
15Department of Neurosurgery, The Cancer Hospital of the University of Chinese Academy of Sciences [Zhejiang Cancer Hospital Institute of Basic Medicine and Cancer (IBMC)], Chinese Academy of Sciences, Hangzhou 310022, China
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Yuanyuan Chen
16Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
17United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China
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  • For correspondence: chenyy2{at}sysucc.org.cn chenming{at}sysucc.org.cn
Ming Chen
1Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China
16Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
17United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China
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  • ORCID record for Ming Chen
  • For correspondence: chenyy2{at}sysucc.org.cn chenming{at}sysucc.org.cn
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Cancer Biology & Medicine: 21 (5)
Cancer Biology & Medicine
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Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase II trial
Shuzhen Lai, Peijing Li, Xiaohui Liu, Guihong Liu, Tieming Xie, Xing Zhang, Xiaoxuan Wang, Jing Huang, Yiqiang Tang, Zhigang Liu, Guoping Shen, Chaoming Li, Fangxiao Lu, Lei Wang, Fagui Jiang, Caixing Sun, Yuanyuan Chen, Ming Chen
Cancer Biology & Medicine May 2024, 21 (5) 433-444; DOI: 10.20892/j.issn.2095-3941.2023.0373

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Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase II trial
Shuzhen Lai, Peijing Li, Xiaohui Liu, Guihong Liu, Tieming Xie, Xing Zhang, Xiaoxuan Wang, Jing Huang, Yiqiang Tang, Zhigang Liu, Guoping Shen, Chaoming Li, Fangxiao Lu, Lei Wang, Fagui Jiang, Caixing Sun, Yuanyuan Chen, Ming Chen
Cancer Biology & Medicine May 2024, 21 (5) 433-444; DOI: 10.20892/j.issn.2095-3941.2023.0373
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Keywords

  • Glioblastoma
  • anti-angiogenesis
  • multi-kinase inhibitor
  • Anlotinib
  • temozolomide
  • progression-free survival

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