Research ArticleOriginal Article
Open Access

Enhancement of anti-PD-L1 antibody plus anlotinib efficacy due to downregulation of PD-L1 in the micro-conduit endothelium within the tumor: a randomized double-blind trial

Cuicui Zhang, Tianqing Chu, Qiming Wang, Ying Cheng, Yongxiang Zhang, Ruili Wang, Leilei Ma, Chaonan Qian, Baohui Han and Kai Li
Cancer Biology & Medicine October 2024, 21 (10) 951-962; DOI: https://doi.org/10.20892/j.issn.2095-3941.2023.0423

Article Information

vol. 21 no. 10 951-962
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2023.0423
PubMed 
38809003
Published By 
Cancer Biology & Medicine
History 
  • Received November 14, 2023
  • Accepted April 23, 2024
  • Published online October 30, 2024.

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Copyright & Usage 
Copyright: © 2024 The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Author Information

  1. Cuicui Zhang1,*,
  2. Tianqing Chu2,*,
  3. Qiming Wang3,
  4. Ying Cheng4,
  5. Yongxiang Zhang5,
  6. Ruili Wang6,
  7. Leilei Ma7,
  8. Chaonan Qian8⇑,
  9. Baohui Han2⇑ and
  10. Kai Li1⇑
  1. 1Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
  2. 2Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
  3. 3Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450003, China
  4. 4Department of Thoracic Medical Oncology, Jilin Cancer Hospital, Changchun 130012, China
  5. 5Department of Respiratory & Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300222, China
  6. 6Panovue Biotechnology (Beijing) Co., Ltd, Beijing 100096, China
  7. 7Medical Affairs Department, Chia-Tai Tian Qing Pharmaceutical Co., Ltd., Nanjing 210046, China
  8. 8Department of Radiation Oncology, Guangzhou Concord Cancer Center, Guangzhou 510555, China
  1. Correspondence to: Chaonan Qian, Baohui Han and Kai Li E-mail: chaonan.qian{at}ccm.cn, 18930858216{at}163.com and likai_fnk{at}163.com
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