Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
OtherPerspective

Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity

Qingyu Lin, Jiaqi Zhu and Ying Hu
Cancer Biology & Medicine August 2023, 20 (8) 553-561; DOI: https://doi.org/10.20892/j.issn.2095-3941.2023.0163
Qingyu Lin
1School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
2Zhengzhou Research Institute of Harbin Institute of Technology, Zhengzhou 450000, China
3Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases, Ministry of Industry and Information Technology, Zhengzhou 450000, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiaqi Zhu
2Zhengzhou Research Institute of Harbin Institute of Technology, Zhengzhou 450000, China
4School of Astronautics, Harbin Institute of Technology, Harbin 150001, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ying Hu
1School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
2Zhengzhou Research Institute of Harbin Institute of Technology, Zhengzhou 450000, China
3Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases, Ministry of Industry and Information Technology, Zhengzhou 450000, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Morad G,
    2. Helmink BA,
    3. Sharma P,
    4. Wargo JA.
    Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 2021; 184: 5309–37.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Zeni PF,
    2. Mraz M.
    LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA Biol. 2021; 18: 619–32.
    OpenUrlCrossRef
  3. 3.↵
    1. Xu S,
    2. Wang Q,
    3. Kang Y,
    4. Liu J,
    5. Yin Y,
    6. Liu L, et al.
    Long noncoding RNAs control the modulation of immune checkpoint molecules in cancer. Cancer Immunol Res. 2020; 8: 937–51.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Mowel WK,
    2. Kotzin JJ,
    3. McCright SJ,
    4. Neal VD,
    5. Henao-Mejia J.
    Control of immune cell homeostasis and function by lncRNAs. Trends Immunol. 2018; 39: 55–69.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Herbst RS,
    2. Soria JC,
    3. Kowanetz M,
    4. Fine GD,
    5. Hamid O,
    6. Gordon MS, et al.
    Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014; 515: 563–7.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Lucibello G,
    2. Mograbi B,
    3. Milano G,
    4. Hofman P,
    5. Brest P.
    PD-L1 regulation revisited: impact on immunotherapeutic strategies. Trends Mol Med. 2021; 27: 868–81.
    OpenUrl
  7. 7.↵
    1. Ghafouri-Fard S,
    2. Shoorei H,
    3. Hussen BM,
    4. Poornajaf Y,
    5. Taheri M,
    6. Sharifi G.
    Interplay between programmed death-ligand 1 and non-coding RNAs. Front Immunol. 2022; 13: 982902.
  8. 8.↵
    1. Jiang W,
    2. Pan S,
    3. Chen X,
    4. Wang ZW,
    5. Zhu X.
    The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy. Mol Cancer. 2021; 20: 116.
    OpenUrl
  9. 9.↵
    1. Park EG,
    2. Pyo SJ,
    3. Cui Y,
    4. Yoon SH,
    5. Nam JW.
    Tumor immune microenvironment lncRNAs. Brief Bioinform. 2022; 23: bbab504.
  10. 10.↵
    1. Demaria O,
    2. Cornen S,
    3. Daëron M,
    4. Morel Y,
    5. Medzhitov R,
    6. Vivier E.
    Harnessing innate immunity in cancer therapy. Nature. 2019; 574: 45–56.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Zhang Y,
    2. Cao X.
    Long noncoding RNAs in innate immunity. Mol Immunol. 2016; 13: 138–47.
    OpenUrl
  12. 12.↵
    1. Guo Y,
    2. Xie Y,
    3. Luo Y.
    The role of long non-coding RNAs in the tumor immune microenvironment. Front Immunol. 2022; 13: 851004.
  13. 13.
    1. Yu H,
    2. Chen C,
    3. Han F,
    4. Tang J,
    5. Deng M,
    6. Niu Y, et al.
    Long noncoding RNA MIR4435-2HG suppresses colorectal cancer initiation and progression by reprogramming neutrophils. Cancer Immunol Res. 2022; 10: 1095–110.
    OpenUrl
  14. 14.↵
    1. Atianand MK,
    2. Caffrey DR,
    3. Fitzgerald KA.
    Immunobiology of long noncoding RNAs. Annu Rev Immunol. 2017; 35: 177–98.
    OpenUrlCrossRefPubMed
  15. 15.
    1. Pi YN,
    2. Qi WC,
    3. Xia BR,
    4. Lou G,
    5. Jin WL.
    Long non-coding RNAs in the tumor immune microenvironment: biological properties and therapeutic potential. Front Immunol. 2021; 12: 697083.
  16. 16.↵
    1. De Mey W,
    2. Esprit A,
    3. Thielemans K,
    4. Breckpot K,
    5. Franceschini L.
    RNA in cancer immunotherapy: unlocking the potential of the immune system. Clin Cancer Res. 2022; 28: 3929–39.
    OpenUrl
  17. 17.↵
    1. Pastor F,
    2. Berraondo P,
    3. Etxeberria I,
    4. Frederick J,
    5. Sahin U,
    6. Gilboa E, et al.
    An RNA toolbox for cancer immunotherapy. Nat Rev Drug Discov. 2018; 17: 751–67.
    OpenUrlPubMed
  18. 18.↵
    1. Winkle M,
    2. El-Daly SM,
    3. Fabbri M,
    4. Calin GA.
    Noncoding RNA therapeutics - challenges and potential solutions. Nat Rev Drug Discov. 2021; 20: 629–51.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Paunovska K,
    2. Loughrey D,
    3. Dahlman JE.
    Drug delivery systems for RNA therapeutics. Nat Rev Genet. 2022; 23: 265–80.
    OpenUrlCrossRef
  20. 20.↵
    1. Lin Q,
    2. Liu T,
    3. Wang X,
    4. Hou G,
    5. Xiang Z,
    6. Zhang W, et al.
    Long noncoding RNA HITT coordinates with RGS2 to inhibit Pd-L1 translation in T cell immunity. J Clin Invest. 2023; 133: e162951.
  21. 21.↵
    1. Lu B,
    2. Javidi-Parsijani P,
    3. Makani V,
    4. Mehraein-Ghomi F,
    5. Sarhan WM,
    6. Sun D, et al.
    Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing. Nucleic Acids Res. 2019; 47: e44.
  22. 22.↵
    1. Hu Q,
    2. Ye Y,
    3. Chan LC,
    4. Li Y,
    5. Liang K,
    6. Lin A, et al.
    Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019; 20: 835–51.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Cancer Biology & Medicine: 20 (8)
Cancer Biology & Medicine
Vol. 20, Issue 8
15 Aug 2023
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Cancer Biology & Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity
(Your Name) has sent you a message from Cancer Biology & Medicine
(Your Name) thought you would like to see the Cancer Biology & Medicine web site.
Citation Tools
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity
Qingyu Lin, Jiaqi Zhu, Ying Hu
Cancer Biology & Medicine Aug 2023, 20 (8) 553-561; DOI: 10.20892/j.issn.2095-3941.2023.0163

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Involvement of lncRNAs in the tumor microenvironment: a new property of tumor immunity
Qingyu Lin, Jiaqi Zhu, Ying Hu
Cancer Biology & Medicine Aug 2023, 20 (8) 553-561; DOI: 10.20892/j.issn.2095-3941.2023.0163
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Regulation of the PD-1/PD-L1 pathway in cancer by lncRNAs
    • LncRNAs regulate innate immune cells in the tumor immune microenvironment (TIME)
    • LncRNAs regulate adaptive immune cells in the TIME
    • RNA therapeutic prospects
    • LncRNA-based cancer immunotherapy
    • Conflict of interest statement
    • Author contributions
    • Acknowledgements
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • The evidence and concerns about screening ultrasound for breast cancer
  • Insights into the DNA damage response and tumor drug resistance
  • Current status of multiple markers in precision immunotherapy for colorectal cancer
Show more Perspective

Similar Articles

Navigate

  • Home
  • Current Issue

More Information

  • About CBM
  • About CACA
  • About TMUCIH
  • Editorial Board
  • Subscription

For Authors

  • Instructions for authors
  • Journal Policies
  • Submit a Manuscript

Journal Services

  • Email Alerts
  • Facebook
  • RSS Feeds
  • Twitter

 

© 2025 Cancer Biology & Medicine

Powered by HighWire