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Research ArticleOriginal Article

Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu and Peng Yuan
Cancer Biology & Medicine February 2023, 20 (2) 155-168; DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0525
Yimeng Chen
1Department of Medical Oncology and Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Xue Wang
2Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Feng Du
1Department of Medical Oncology and Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Jian Yue
2Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Yiran Si
1Department of Medical Oncology and Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Xiaochen Zhao
3The Medical Department, 3D Medicines Inc., Shanghai 201114, China
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Lina Cui
3The Medical Department, 3D Medicines Inc., Shanghai 201114, China
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Bei Zhang
3The Medical Department, 3D Medicines Inc., Shanghai 201114, China
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Ting Bei
3The Medical Department, 3D Medicines Inc., Shanghai 201114, China
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Binghe Xu
1Department of Medical Oncology and Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • For correspondence: yuanpengyp01{at}163.com xubinghebm{at}163.com
Peng Yuan
2Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • ORCID record for Peng Yuan
  • For correspondence: yuanpengyp01{at}163.com xubinghebm{at}163.com
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Article Information

vol. 20 no. 2 155-168
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2022.0525

Published By 
Cancer Biology & Medicine
History 
  • Received August 26, 2022
  • Accepted November 28, 2022
  • Published online March 2, 2023.

Copyright & Usage 
Copyright: © 2023, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Yimeng Chen1,*,
  2. Xue Wang2,*,
  3. Feng Du1,
  4. Jian Yue2,
  5. Yiran Si1,
  6. Xiaochen Zhao3,
  7. Lina Cui3,
  8. Bei Zhang3,
  9. Ting Bei3,
  10. Binghe Xu1⇑ and
  11. Peng Yuan2⇑
  1. 1Department of Medical Oncology and Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  2. 2Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  3. 3The Medical Department, 3D Medicines Inc., Shanghai 201114, China
  1. Correspondence to: Peng Yuan and Binghe Xu, Email: yuanpengyp01{at}163.com and xubinghebm{at}163.com
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Cancer Biology & Medicine: 20 (2)
Cancer Biology & Medicine
Vol. 20, Issue 2
15 Feb 2023
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Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer
Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu, Peng Yuan
Cancer Biology & Medicine Feb 2023, 20 (2) 155-168; DOI: 10.20892/j.issn.2095-3941.2022.0525

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Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer
Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu, Peng Yuan
Cancer Biology & Medicine Feb 2023, 20 (2) 155-168; DOI: 10.20892/j.issn.2095-3941.2022.0525
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Keywords

  • homologous recombination deficiency
  • Triple-negative breast cancer
  • platinum
  • survival
  • BRCA

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