OtherConsensus
2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Ping Li, Yang Liu, Yun Liang, Jian Bo, Sujun Gao, Yongxian Hu, Yu Hu, He Huang, Xiaojun Huang, Hongmei Jing, Xiaoyan Ke, Jianyong Li, Yuhua Li, Qifa Liu, Peihua Lu, Heng Mei, Ting Niu, Yongping Song, Yuqin Song, Liping Su, Sanfang Tu, Jianxiang Wang, Depei Wu, Zhao Wang, Kailin Xu, Zhitao Ying, Qingming Yang, Yajing Zhang, Fengxia Shi, Bin Zhang, Huilai Zhang, Xi Zhang, Mingfeng Zhao, Weili Zhao, Xiangyu Zhao, Liang Huang, Jun Zhu, Wenbin Qian, Weidong Han and Aibin Liang
Cancer Biology & Medicine February 2023, 20 (2) 129-146; DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0585
Ping Li
1Department of Hematology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
Yang Liu
2Department of Bio-therapeutic, Chinese PLA General Hospital, Beijing 100853, China
Yun Liang
3Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China
Jian Bo
4Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China
Sujun Gao
5Department of Hematology, The First Hospital of Jilin University, Changchun 130012, China
Yongxian Hu
6Center for Bone Marrow Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China
Yu Hu
7Institute of Hematology, Union Hospital of Tongji Medical College; Huazhong University of Science and Technology, Wuhan 430022, China
He Huang
6Center for Bone Marrow Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China
Xiaojun Huang
8Peking University People’s Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China
Hongmei Jing
9Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191, China
Xiaoyan Ke
9Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191, China
Jianyong Li
10Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China
Yuhua Li
11Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China
Qifa Liu
12Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Peihua Lu
13Lu Daopei Institute of Hematology, Beijing 101102, China
Heng Mei
7Institute of Hematology, Union Hospital of Tongji Medical College; Huazhong University of Science and Technology, Wuhan 430022, China
Ting Niu
14Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China
Yongping Song
15The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China
Yuqin Song
16Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China
Liping Su
17Department of Hematology, Shanxi Cancer Hospital, Taiyuan 030013, China
Sanfang Tu
11Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China
Jianxiang Wang
18State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Division of Pediatric Blood Disease Center, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
Depei Wu
19Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou 215006, China
Zhao Wang
20Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Kailin Xu
21Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China
Zhitao Ying
16Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China
Qingming Yang
2Department of Bio-therapeutic, Chinese PLA General Hospital, Beijing 100853, China
Yajing Zhang
2Department of Bio-therapeutic, Chinese PLA General Hospital, Beijing 100853, China
Fengxia Shi
2Department of Bio-therapeutic, Chinese PLA General Hospital, Beijing 100853, China
Bin Zhang
22Institute of Blood and Marrow Transplantation, The Fifth Medical Center, Chinese PLA General Hospital, Beijing 100039, China
Huilai Zhang
23Department of Lymphoma, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
Xi Zhang
24Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing 400037, China
Mingfeng Zhao
25Department of Hematology, Tianjin First Central Hospital, Tianjin 300192, China
Weili Zhao
26Department of Hematology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Xiangyu Zhao
8Peking University People’s Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China
Liang Huang
27Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Jun Zhu
16Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China
Wenbin Qian
3Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China
Weidong Han
2Department of Bio-therapeutic, Chinese PLA General Hospital, Beijing 100853, China
Aibin Liang
1Department of Hematology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
References
- 1.↵
- 2.
- Chavez JC,
- Locke FL.
- 3.↵
- Minghan Q,
- Shan W,
- Xinrui C,
- Huaqing W.
- 4.↵
- 5.
- Reagan PM,
- Friedberg JW.
- 6.
- Hayden PJ,
- Roddie C,
- Bader P,
- Basak GW,
- Bonig H,
- Bonini C, et al.
- 7.↵
- Nuvvula S,
- Dahiya S,
- Patel SA.
- 8.↵
- 9.↵
- Ying Z,
- Yang H,
- Guo Y,
- Li W,
- Zou D,
- Zhou D, et al.
- 10.↵
- Zhu H,
- Deng H,
- Mu J,
- Lyu C,
- Jiang Y,
- Deng Q.
- 11.
- Zhang WY,
- Wang Y,
- Guo YL,
- Dai HR,
- Yang QM,
- Zhang YJ, et al.
- 12.↵
- Deng W,
- Chen P,
- Lei W,
- Xu Y,
- Xu N,
- Pu JJ, et al.
- 13.↵
- 14.
- 15.↵
- 16.↵
- Sang W,
- Shi M,
- Yang J,
- Cao J,
- Xu L,
- Yan D, et al.
- 17.
- Zeng C,
- Cheng J,
- Li T,
- Huang J,
- Li C,
- Jiang L, et al.
- 18.↵
- Cao Y,
- Xiao Y,
- Wang N,
- Wang G,
- Huang L,
- Hong Z, et al.
- 19.↵
- Los-Arcos I,
- Iacoboni G,
- Aguilar-Guisado M,
- Alsina-Manrique L,
- Díaz de Heredia C,
- Fortuny-Guasch C, et al.
- 20.
- Schmidts A,
- Wehrli M,
- Maus MV.
- 21.↵
- 22.↵
- Han L,
- Zhou J,
- Li L,
- Zhou K,
- Zhao L,
- Zhu X, et al.
- 23.↵
- Yang X,
- Wang GX,
- Zhou JF.
- 24.
- Holstein SA,
- Lunning MA.
- 25.
- 26.↵Specialty Committee of Biotherapy tCRHA. Experts consensus on clinical management of toxicity associated with CAR T cell therapy in non-Hodgkin’s lymphoma (NHL). Transl Med. 2021; 10: 1–11.
- 27.↵
- Wei J,
- Liu Y,
- Wang C,
- Zhang Y,
- Tong C,
- Dai G, et al.
- 28.↵
- 29.↵
- 30.↵
- 31.↵
- Oken MM,
- Creech RH,
- Tormey DC,
- Horton J,
- Davis TE,
- McFadden ET, et al.
- 32.↵
- Brepoels L,
- Stroobants S,
- De Wever W,
- Spaepen K,
- Vandenberghe P,
- Thomas J, et al.
- 33.↵
- 34.↵
- 35.↵
- 36.↵
- 37.↵
- 38.↵
- 39.↵
- Hay KA,
- Hanafi LA,
- Li D,
- Gust J,
- Liles WC,
- Wurfel MM, et al.
- 40.↵
- 41.↵
- Liu Y,
- Fang Y,
- Chen X,
- Wang Z,
- Liang X,
- Zhang T, et al.
- 42.↵
- Wagner DH Jr.,
- Stout RD,
- Suttles J.
- 43.↵
- McInnes IB,
- Leung BP,
- Sturrock RD,
- Field M,
- Liew FY.
- 44.↵
- Avice MN,
- Sarfati M,
- Triebel F,
- Delespesse G,
- Demeure CE.
- 45.↵
- Birkland TP,
- Sypek JP,
- Wyler DJ.
- 46.↵
- Mirza AS,
- Kumar A,
- Hashmi H,
- Garcia F,
- Logothetis CN,
- Darwin A, et al.
- 47.↵
- Zahid A,
- Siegler EL,
- Kenderian SS.
- 48.
- Xiao X,
- Huang S,
- Chen S,
- Wang Y,
- Sun Q,
- Xu X, et al.
- 49.↵
- Cosenza M,
- Sacchi S,
- Pozzi S.
- 50.↵
- Qian WB,
- Liu H.
- 51.↵
- Brudno JN,
- Kochenderfer JN.
- 52.↵
- Cortes-Bullich A,
- Perez A,
- Bachmeier C,
- Mhaskar R,
- Chavez JC,
- Shah B, et al.
- 53.↵
- Hu Y,
- Wang J,
- Pu C,
- Zhao K,
- Cui Q,
- Wei G, et al.
- 54.↵
- Alvi RM,
- Frigault MJ,
- Fradley MG,
- Jain MD,
- Mahmood SS,
- Awadalla M, et al.
- 55.↵
- Burns EA,
- Gentille C,
- Trachtenberg B,
- Pingali SR,
- Anand K.
- 56.↵
- Catino AB.
- 57.
- Simbaqueba CC,
- Aponte MP,
- Kim P,
- Deswal A,
- Palaskas NL,
- Iliescu C, et al.
- 58.↵
- Steiner RE,
- Banchs J,
- Koutroumpakis E,
- Becnel M,
- Gutierrez C,
- Strati P, et al.
- 59.↵
- 60.↵
- 61.↵
- Chou CK,
- Turtle CJ.
- 62.↵
- 63.↵
- 64.↵
- 65.↵
- Takao M.
- 66.↵
- Cornillon J,
- Hadhoum N,
- Roth-Guepin G,
- Quessar A,
- Platon L,
- Ouachée-Chardin M, et al.
- 67.↵
- 68.↵
- Westin JR,
- Kersten MJ,
- Salles G,
- Abramson JS,
- Schuster SJ,
- Locke FL, et al.
- 69.
- Cao JX,
- Wang H,
- Gao WJ,
- You J,
- Wu LH,
- Wang ZX.
- 70.↵
- 71.↵
- 72.↵
- Karschnia P,
- Jordan JT,
- Forst DA,
- Arrillaga-Romany IC,
- Batchelor TT,
- Baehring JM, et al.
- 73.↵
- 74.↵
- 75.↵
- 76.↵
- 77.
- Griffin G,
- Shenoi S,
- Hughes GC.
- 78.↵
- Sandler RD,
- Tattersall RS,
- Schoemans H,
- Greco R,
- Badoglio M,
- Labopin M, et al.
- 79.↵
- Shalabi H,
- Gust J,
- Taraseviciute A,
- Wolters PL,
- Leahy AB,
- Sandi C, et al.
- 80.↵
- Maude SL,
- Barrett D,
- Teachey DT,
- Grupp SA.
- 81.↵
- Teachey DT,
- Lacey SF,
- Shaw PA,
- Melenhorst JJ,
- Maude SL,
- Frey N, et al.
- 82.↵
- Ramos-Casals M,
- Brito-Zerón P,
- López-Guillermo A,
- Khamashta MA,
- Bosch X.
- 83.
- 84.↵
- Brisse E,
- Matthys P,
- Wouters CH.
- 85.↵
- 86.↵
- Schaefer A,
- Huang Y,
- Kittai A,
- Maakaron JE,
- Saygin C,
- Brammer J, et al.
- 87.↵
- Brudno JN,
- Natrakul D,
- Lam N,
- Dulau-Florea A,
- Yuan CM,
- Kochenderfer JN.
- 88.↵
- 89.↵
- 90.↵
- Hill JA,
- Li D,
- Hay KA,
- Green ML,
- Cherian S,
- Chen X, et al.
- 91.↵
- 92.↵
- Maude SL,
- Frey N,
- Shaw PA,
- Aplenc R,
- Barrett DM,
- Bunin NJ, et al.
- 93.↵
- Kochenderfer JN,
- Dudley ME,
- Feldman SA,
- Wilson WH,
- Spaner DE,
- Maric I, et al.
- 94.↵
- Lee DW,
- Gardner R,
- Porter DL,
- Louis CU,
- Ahmed N,
- Jensen M, et al.
- 95.↵
- Li P,
- Zhou L,
- Ye S,
- Zhang W,
- Wang J,
- Tang X, et al.
- 96.↵
- Kusumoto S,
- Tobinai K.
- 97.↵
- Haidar G,
- Garner W,
- Hill JA.
- 98.↵
- Link H,
- Böhme A,
- Cornely OA,
- Höffken K,
- Kellner O,
- Kern WV, et al.
- 99.↵
- Kampouri E,
- Walti CS,
- Gauthier J,
- Hill JA.
- 100.↵
- Juluri KR,
- Wu QV,
- Voutsinas J,
- Hou J,
- Hirayama AV,
- Mullane E, et al.
- 101.↵
- Gupta A,
- Moore JA.
- 102.↵
- Howard SC,
- Jones DP,
- Pui CH.
- 103.↵
- 104.↵
- Coiffier B,
- Altman A,
- Pui CH,
- Younes A,
- Cairo MS.
- 105.↵
- Muslimani A,
- Chisti MM,
- Wills S,
- Nadeau L,
- Zakalik D,
- Daw H, et al.
- 106.↵
- Esmaeilzadeh A,
- Tahmasebi S,
- Athari SS.
- 107.↵
- Zhang WY,
- Liu Y,
- Wang Y,
- Nie J,
- Guo YL,
- Wang CM, et al.
- 108.↵
- 109.↵
- Friedberg JW,
- Neuberg D,
- Stone RM,
- Alyea E,
- Jallow H,
- LaCasce A, et al.
- 110.
- Tward JD,
- Wendland MM,
- Shrieve DC,
- Szabo A,
- Gaffney DK.
- 111.
- Travis LB,
- Curtis RE,
- Glimelius B,
- Holowaty E,
- Van Leeuwen FE,
- Lynch CF, et al.
- 112.
- 113.↵
- 114.↵
- Pirani M,
- Marcheselli R,
- Marcheselli L,
- Bari A,
- Federico M,
- Sacchi S.
- 115.↵
- Morton LM,
- Curtis RE,
- Linet MS,
- Bluhm EC,
- Tucker MA,
- Caporaso N, et al.
In this issue
2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Ping Li, Yang Liu, Yun Liang, Jian Bo, Sujun Gao, Yongxian Hu, Yu Hu, He Huang, Xiaojun Huang, Hongmei Jing, Xiaoyan Ke, Jianyong Li, Yuhua Li, Qifa Liu, Peihua Lu, Heng Mei, Ting Niu, Yongping Song, Yuqin Song, Liping Su, Sanfang Tu, Jianxiang Wang, Depei Wu, Zhao Wang, Kailin Xu, Zhitao Ying, Qingming Yang, Yajing Zhang, Fengxia Shi, Bin Zhang, Huilai Zhang, Xi Zhang, Mingfeng Zhao, Weili Zhao, Xiangyu Zhao, Liang Huang, Jun Zhu, Wenbin Qian, Weidong Han, Aibin Liang
Cancer Biology & Medicine Feb 2023, 20 (2) 129-146; DOI: 10.20892/j.issn.2095-3941.2022.0585
2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma
Ping Li, Yang Liu, Yun Liang, Jian Bo, Sujun Gao, Yongxian Hu, Yu Hu, He Huang, Xiaojun Huang, Hongmei Jing, Xiaoyan Ke, Jianyong Li, Yuhua Li, Qifa Liu, Peihua Lu, Heng Mei, Ting Niu, Yongping Song, Yuqin Song, Liping Su, Sanfang Tu, Jianxiang Wang, Depei Wu, Zhao Wang, Kailin Xu, Zhitao Ying, Qingming Yang, Yajing Zhang, Fengxia Shi, Bin Zhang, Huilai Zhang, Xi Zhang, Mingfeng Zhao, Weili Zhao, Xiangyu Zhao, Liang Huang, Jun Zhu, Wenbin Qian, Weidong Han, Aibin Liang
Cancer Biology & Medicine Feb 2023, 20 (2) 129-146; DOI: 10.20892/j.issn.2095-3941.2022.0585
Jump to section
- Article
- Abstract
- Introduction
- Workup and risk assessment for toxicities at baseline
- CRS
- CAR T-cell-associated encephalopathy syndrome
- Hemophagocytic lymphohistiocytosis/macrophage activation syndrome
- Bone marrow suppression
- Infection
- Other toxicities
- Conclusions
- Grant support
- Conflict of interest statement
- Author contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- References
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