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Research ArticleOriginal Article

Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy

Huan Xu, Junyi Chen, Zhi Cao, Xi Chen, Caihong Huang, Jin Ji, Yalong Xu, Junfeng Jiang, Yue Wang, Guowang Xu, Lina Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu, Zhong Wang, Shancheng Ren and Fubo Wang
Cancer Biology & Medicine September 2022, 19 (9) 1315-1333; DOI: https://doi.org/10.20892/j.issn.2095-3941.2021.0638
Huan Xu
1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2Department of Urology, Shanghai Ninth People’s Hospital, Shanghai 200011, China
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Junyi Chen
3Department of Urology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
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Zhi Cao
1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
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Xi Chen
1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
4Department of Urology, No. 971 Hospital of the People’s Liberation Army Navy, Qingdao 266000, China
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Caihong Huang
5Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, China
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Jin Ji
1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
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Yalong Xu
1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
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Junfeng Jiang
6Research Center of Developmental Biology, Second Military Medical University, Shanghai 200433, China
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Yue Wang
6Research Center of Developmental Biology, Second Military Medical University, Shanghai 200433, China
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Guowang Xu
7Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
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Lina Zhou
7Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
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Jingyi He
8Department of Urology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
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Xuedong Wei
8Department of Urology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
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Jason Boyang Wu
9Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA
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Zhong Wang
2Department of Urology, Shanghai Ninth People’s Hospital, Shanghai 200011, China
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Shancheng Ren
1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
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  • For correspondence: [email protected] [email protected]
Fubo Wang
5Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, China
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  • For correspondence: [email protected] [email protected]
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Cancer Biology & Medicine: 19 (9)
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Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy
Huan Xu, Junyi Chen, Zhi Cao, Xi Chen, Caihong Huang, Jin Ji, Yalong Xu, Junfeng Jiang, Yue Wang, Guowang Xu, Lina Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu, Zhong Wang, Shancheng Ren, Fubo Wang
Cancer Biology & Medicine Sep 2022, 19 (9) 1315-1333; DOI: 10.20892/j.issn.2095-3941.2021.0638

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Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy
Huan Xu, Junyi Chen, Zhi Cao, Xi Chen, Caihong Huang, Jin Ji, Yalong Xu, Junfeng Jiang, Yue Wang, Guowang Xu, Lina Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu, Zhong Wang, Shancheng Ren, Fubo Wang
Cancer Biology & Medicine Sep 2022, 19 (9) 1315-1333; DOI: 10.20892/j.issn.2095-3941.2021.0638
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Keywords

  • Glycolytic potential
  • prostate cancer
  • mitochondrial pyruvate carrier (MPC)
  • mitochondria pyruvate influx
  • diagnosis
  • radiotherapy

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