Research ArticleOriginal Article

Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy

Huan Xu, Junyi Chen, Zhi Cao, Xi Chen, Caihong Huang, Jin Ji, Yalong Xu, Junfeng Jiang, Yue Wang, Guowang Xu, Lina Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu, Zhong Wang, Shancheng Ren and Fubo Wang
Cancer Biology & Medicine September 2022, 19 (9) 1315-1333; DOI: https://doi.org/10.20892/j.issn.2095-3941.2021.0638

Article Information

vol. 19 no. 9 1315-1333
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2021.0638
Published By 
Cancer Biology & Medicine
History 
  • Received November 29, 2021
  • Accepted March 2, 2022
  • Published online September 22, 2022.

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Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Huan Xu1,2,*,
  2. Junyi Chen3,*,
  3. Zhi Cao1,
  4. Xi Chen1,4,
  5. Caihong Huang5,
  6. Jin Ji1,
  7. Yalong Xu1,
  8. Junfeng Jiang6,
  9. Yue Wang6,
  10. Guowang Xu7,
  11. Lina Zhou7,
  12. Jingyi He8,
  13. Xuedong Wei8,
  14. Jason Boyang Wu9,
  15. Zhong Wang2,
  16. Shancheng Ren1⇑ and
  17. Fubo Wang5⇑
  1. 1Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  2. 2Department of Urology, Shanghai Ninth People’s Hospital, Shanghai 200011, China
  3. 3Department of Urology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
  4. 4Department of Urology, No. 971 Hospital of the People’s Liberation Army Navy, Qingdao 266000, China
  5. 5Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, China
  6. 6Research Center of Developmental Biology, Second Military Medical University, Shanghai 200433, China
  7. 7Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
  8. 8Department of Urology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
  9. 9Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA
  1. Correspondence to: Fubo Wang and Shancheng Ren, E-mail: wangfubo{at}gxmu.edu.cn and renshancheng{at}gmail.com
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