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Research ArticleOriginal Article

Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer

Qiong Wang, Zean Li, Jin Yang, Shirong Peng, Qianghua Zhou, Kai Yao, Wenli Cai, Zhongqiu Xie, Fujun Qin, Hui Li, Xu Chen, Kaiwen Li and Hai Huang
Cancer Biology & Medicine August 2022, 19 (8) 1193-1210; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0550
Qiong Wang
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
2Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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Zean Li
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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Jin Yang
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
4Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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Shirong Peng
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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Qianghua Zhou
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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Kai Yao
5Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
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Wenli Cai
6Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
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Zhongqiu Xie
2Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
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Fujun Qin
2Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
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Hui Li
2Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
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Xu Chen
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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Kaiwen Li
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
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  • For correspondence: huangh9{at}mail.sysu.edu.cn likw6{at}mail.sysu.edu.cn
Hai Huang
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
7Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan 511518, China
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  • For correspondence: huangh9{at}mail.sysu.edu.cn likw6{at}mail.sysu.edu.cn
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Article Information

vol. 19 no. 8 1193-1210
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0550

Published By 
Cancer Biology & Medicine
History 
  • Received September 13, 2020
  • Accepted January 13, 2021
  • Published online August 29, 2022.

Article Versions

  • previous version (July 15, 2022 - 07:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Qiong Wang1,2,3,*,
  2. Zean Li1,3,*,
  3. Jin Yang3,4,
  4. Shirong Peng1,3,
  5. Qianghua Zhou1,3,
  6. Kai Yao5,
  7. Wenli Cai6,
  8. Zhongqiu Xie2,
  9. Fujun Qin2,
  10. Hui Li2,
  11. Xu Chen1,3,
  12. Kaiwen Li1,3⇑ and
  13. Hai Huang1,3,7⇑
  1. 1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  2. 2Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
  3. 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  4. 4Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  5. 5Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
  6. 6Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  7. 7Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan 511518, China
  1. Correspondence to: Hai Huang and Kaiwen Li, E-mail: huangh9{at}mail.sysu.edu.cn and likw6{at}mail.sysu.edu.cn
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Cancer Biology & Medicine: 19 (8)
Cancer Biology & Medicine
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Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer
Qiong Wang, Zean Li, Jin Yang, Shirong Peng, Qianghua Zhou, Kai Yao, Wenli Cai, Zhongqiu Xie, Fujun Qin, Hui Li, Xu Chen, Kaiwen Li, Hai Huang
Cancer Biology & Medicine Aug 2022, 19 (8) 1193-1210; DOI: 10.20892/j.issn.2095-3941.2020.0550

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Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer
Qiong Wang, Zean Li, Jin Yang, Shirong Peng, Qianghua Zhou, Kai Yao, Wenli Cai, Zhongqiu Xie, Fujun Qin, Hui Li, Xu Chen, Kaiwen Li, Hai Huang
Cancer Biology & Medicine Aug 2022, 19 (8) 1193-1210; DOI: 10.20892/j.issn.2095-3941.2020.0550
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Keywords

  • CRPC
  • NEIL3
  • NEPC
  • Prostate cancer
  • radiotherapy resistance

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