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Review ArticleReview

Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies

Wuyin Wang, Lu Zhang and Zhijun Sun
Cancer Biology & Medicine July 2022, 19 (7) 948-964; DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0049
Wuyin Wang
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
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Lu Zhang
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
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  • For correspondence: [email protected] [email protected]
Zhijun Sun
1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
2Department of Oral Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
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  • For correspondence: [email protected] [email protected]
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Article Information

vol. 19 no. 7 948-964
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2022.0049

Published By 
Cancer Biology & Medicine
History 
  • Received February 1, 2022
  • Accepted May 5, 2022
  • Published online July 27, 2022.

Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Wuyin Wang1,
  2. Lu Zhang1⇑ and
  3. Zhijun Sun1,2⇑
  1. 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  2. 2Department of Oral Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  1. Correspondence to: Lu Zhang and Zhijun Sun, E-mail: luzhang2012{at}whu.edu.cn and sunzj{at}whu.edu.cn
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Cancer Biology & Medicine: 19 (7)
Cancer Biology & Medicine
Vol. 19, Issue 7
15 Jul 2022
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Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies
Wuyin Wang, Lu Zhang, Zhijun Sun
Cancer Biology & Medicine Jul 2022, 19 (7) 948-964; DOI: 10.20892/j.issn.2095-3941.2022.0049

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Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies
Wuyin Wang, Lu Zhang, Zhijun Sun
Cancer Biology & Medicine Jul 2022, 19 (7) 948-964; DOI: 10.20892/j.issn.2095-3941.2022.0049
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  • Article
    • Abstract
    • Introduction
    • Mechanism of pyroptosis
    • Pyroptosis of cancer cells regulates the tumor immune microenvironment
    • Pyroptosis and cancer therapy
    • Potential for synergy between immune checkpoint blockade and localized pyroptosis-inducing therapies
    • Conclusions and perspectives
    • Grant support
    • Conflict of interest statement
    • Author contributions
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

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Keywords

  • Pyroptosis
  • immune checkpoint blockade
  • immunogenic cell death
  • tumor
  • immunotherapy

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