Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
Research ArticleOriginal Article

Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy

Fan Kou, Lei Wu, Yan Guo, Bailu Zhang, Baihui Li, Ziqi Huang, Xiubao Ren and Lili Yang
Cancer Biology & Medicine May 2022, 19 (5) 685-695; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0728
Fan Kou
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lei Wu
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yan Guo
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bailu Zhang
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Baihui Li
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ziqi Huang
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiubao Ren
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
2Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Xiubao Ren
  • For correspondence: yanglili{at}tjmuch.com renxiubao{at}tjmuch.com
Lili Yang
1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Immunology and Biotherapy, Tianjin 300060, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lili Yang
  • For correspondence: yanglili{at}tjmuch.com renxiubao{at}tjmuch.com
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Siegel RL,
    2. Miller KD,
    3. Jemal A.
    Cancer statistics, 2018. CA Cancer J Clin. 2018; 68: 7–30.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Chan C,
    2. Lang S,
    3. Rowbottom C,
    4. Guckenberger M,
    5. Faivre-Finn C.
    IASLC Advanced Radiation Technology Committee. Intensity-modulated radiotherapy for lung cancer: current status and future developments. J Thorac Oncol. 2014; 9: 1598–608.
    OpenUrlPubMed
  3. 3.↵
    1. De Ruysscher D,
    2. Lueza B,
    3. Le Péchoux C,
    4. Johnson D,
    5. O’Brien M,
    6. Murray N, et al.
    Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis. Ann Oncol. 2016; 27: 1818–28.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Wang J,
    2. Zhao Y,
    3. Wang Q,
    4. Zhang L,
    5. Shi J,
    6. Wang Z, et al.
    Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment. Cancer Biol Med. 2018; 15: 443–51.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Goodman CR,
    2. Seagle BL,
    3. Friedl TWP,
    4. Rack B,
    5. Lato K,
    6. Fink V, et al.
    Association of circulating tumor cell status with benefit of radiotherapy and survival in early-stage breast cancer. JAMA Oncol. 2018; 4: e180163.
  6. 6.↵
    1. Chan CHF,
    2. Wong P.
    Molecular predictors of radiotherapy response in sarcoma. Curr Treat Options Oncol. 2016; 17: 2.
    OpenUrl
  7. 7.↵
    1. Holland AJ,
    2. Cleveland DW.
    Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 2009; 10: 478–87.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Davoli T,
    2. Uno H,
    3. Wooten EC,
    4. Elledge SJ.
    Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017; 355: eaaf8399.
  9. 9.↵
    1. Hieronymus H,
    2. Murali R,
    3. Tin A,
    4. Yadav K,
    5. Abida W,
    6. Moller H, et al.
    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death. Elife. 2018; 7: e37294.
  10. 10.↵
    1. Kim H,
    2. Cha H,
    3. Kim J,
    4. Park W,
    5. Choi Y,
    6. Sun J, et al.
    Genomic scoring to determine clinical benefit of immunotherapy by targeted sequencing. Eur J Cancer. 2019; 120: 65–74.
    OpenUrlPubMed
  11. 11.↵
    1. Killcoyne S,
    2. Gregson E,
    3. Wedge D,
    4. Woodcock D,
    5. Eldridge M,
    6. de la Rue R, et al.
    Genomic copy number predicts esophageal cancer years before transformation. Nat Med. 2020; 26: 1726–32.
    OpenUrlPubMed
  12. 12.↵
    1. Kou F,
    2. Wu L,
    3. Ren X,
    4. Yang L.
    Chromosome abnormalities: new insights into their clinical significance in cancer. Mol Ther Oncolytics. 2020; 17: 562–70.
    OpenUrl
  13. 13.↵
    1. Thorsson V,
    2. Gibbs DL,
    3. Brown SD,
    4. Wolf D,
    5. Bortone DS,
    6. Ou Yang TH, et al.
    The immune landscape of cancer. Immunity. 2018; 48: 812–30.e14.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Hartaigh BÓ,
    2. Gransar H,
    3. Callister T,
    4. Shaw LJ,
    5. Schulman-Marcus J,
    6. Stuijfzand WJ, et al.
    Development and validation of a simple-to-use nomogram for predicting 5-, 10-, and 15-year survival in asymptomatic adults undergoing coronary artery calcium scoring. JACC Cardiovasc Imaging. 2018; 11: 450–8.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. An C,
    2. Li X,
    3. Yu X,
    4. Cheng Z,
    5. Han Z,
    6. Liu F, et al.
    Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation. Cancer Biol Med. 2019; 16: 797–810.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Subramanian A,
    2. Tamayo P,
    3. Mootha VK,
    4. Mukherjee S,
    5. Ebert BL,
    6. Gillette MA, et al.
    Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005; 102: 15545–50.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Campbell JD,
    2. Alexandrov A,
    3. Kim J,
    4. Wala J,
    5. Berger AH,
    6. Pedamallu CS, et al.
    Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. Nat Genet. 2016; 48: 607–16.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Swanton C,
    2. Govindan R.
    Clinical implications of genomic discoveries in lung cancer. N Engl J Med. 2016; 374: 1864–73.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Shukla AK,
    2. Tripathi D.
    Detecting biomarkers from microarray data using distributed correlation based gene selection. Genes Genomics. 2020; 42: 449–65.
    OpenUrl
  20. 20.
    1. Zaccaria S,
    2. Raphael BJ.
    Accurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing data. Nat Commun. 2020; 11: 4301.
    OpenUrlCrossRefPubMed
  21. 21.
    1. Jiao Q,
    2. Sun H,
    3. Zhang H,
    4. Wang R,
    5. Li S,
    6. Sun D, et al.
    The combination of whole-exome sequencing and copy number variation sequencing enables the diagnosis of rare neurological disorders. Clin Genet. 2019; 96: 140–50.
    OpenUrl
  22. 22.↵
    1. Nam JY,
    2. Kim NK,
    3. Kim SC,
    4. Joung JG,
    5. Xi R,
    6. Lee S, et al.
    Evaluation of somatic copy number estimation tools for whole-exome sequencing data. Brief Bioinform. 2016; 17: 185–92.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Pinto AE,
    2. Pires A,
    3. Silva G,
    4. Bicho C,
    5. André S,
    6. Soares J.
    Ploidy and S-phase fraction as predictive markers of response to radiotherapy in cervical cancer. Pathol Res Pract. 2011; 207: 623–7.
    OpenUrlPubMed
  24. 24.
    1. Moureau-Zabotto L,
    2. Bouchet C,
    3. Cesari D,
    4. Uzan S,
    5. Lefranc JP,
    6. Antoine M, et al.
    Combined flow cytometry determination of S-phase fraction and DNA ploidy is an independent prognostic factor in node-negative invasive breast carcinoma: analysis of a series of 271 patients with stage I and II breast cancer. Breast Cancer Res Treat. 2005; 91: 61–71.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Subtil-Rodríguez A,
    2. Vázquez-Chávez E,
    3. Ceballos-Chávez M,
    4. Rodríguez-Paredes M,
    5. Martín-Subero JI,
    6. Esteller M, et al.
    The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes. Nucleic Acids Res. 2014; 42: 2185–96.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Liu R,
    2. Qu Y,
    3. Chen L,
    4. Pu J,
    5. Ma S,
    6. Zhang X, et al.
    Genomic copy number gains of ErbB family members predict poor clinical outcomes in glioma patients. Oncotarget. 2017; 8: 92275–88.
    OpenUrl
  27. 27.↵
    1. Zafarana G,
    2. Ishkanian AS,
    3. Malloff CA,
    4. Locke JA,
    5. Sykes J,
    6. Thoms J, et al.
    Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy. Cancer. 2012; 118: 4053–62.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Wang Z,
    2. Zhang L,
    3. He L,
    4. Cui D,
    5. Liu C,
    6. Yin L, et al.
    Low-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma. Chin J Cancer Res. 2020; 32: 334–46.
    OpenUrl
  29. 29.↵
    1. Lei Y,
    2. Sun N,
    3. Zhang G,
    4. Liu C,
    5. Lu Z,
    6. Huang J, et al.
    Combined detection of aneuploid circulating tumor-derived endothelial cells and circulating tumor cells may improve diagnosis of early stage non-small-cell lung cancer. Clin Transl Med. 2020; 10: e128.
  30. 30.↵
    1. Jamal-Hanjani M,
    2. Wilson GA,
    3. McGranahan N,
    4. Birkbak NJ,
    5. Watkins TB,
    6. Veeriah S, et al.
    Tracking the evolution of non-small-cell lung cancer. N Engl J Med. 2017; 376: 2109–21.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Hao P,
    2. LeBlanc SJ,
    3. Case BC,
    4. Elston TC,
    5. Hingorani MM,
    6. Erie DA, et al.
    Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby. Proc Natl Acad Sci U S A. 2020; 117: 17775–84.
    OpenUrlAbstract/FREE Full Text
  32. 32.↵
    1. Siegel JJ,
    2. Amon A.
    New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol. 2012; 28: 189–214.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Turajlic S,
    2. Sottoriva A,
    3. Graham T,
    4. Swanton C.
    Resolving genetic heterogeneity in cancer. Nat Rev Genet. 2019; 20: 404–16.
    OpenUrl
  34. 34.↵
    1. He Y,
    2. Liu ZX,
    3. Jiang ZH,
    4. Wang XS.
    Identification of genomic features associated with immunotherapy response in gastrointestinal cancers. World J Gastrointest Oncol. 2019; 11: 270–80.
    OpenUrl
  35. 35.↵
    1. Li B,
    2. Cui Y,
    3. Nambiar DK,
    4. Sunwoo JB,
    5. Li R.
    The immune subtypes and landscape of squamous cell carcinoma. Clin Cancer Res. 2019; 25: 3528–37.
    OpenUrlAbstract/FREE Full Text
  36. 36.↵
    1. Sayles LC,
    2. Breese MR,
    3. Koehne AL,
    4. Leung SG,
    5. Lee AG,
    6. Liu HY, et al.
    Genome-informed targeted therapy for osteosarcoma. Cancer Discov. 2019; 9: 46–63.
    OpenUrlAbstract/FREE Full Text
  37. 37.↵
    1. Wang DS,
    2. Liu ZX,
    3. Lu YX,
    4. Bao H,
    5. Wu X,
    6. Zeng ZL, et al.
    Liquid biopsies to track trastuzumab resistance in metastatic HER2-positive gastric cancer. Gut. 2019; 68: 1152–61.
    OpenUrlAbstract/FREE Full Text
  38. 38.↵
    1. Shao X,
    2. Lv N,
    3. Liao J,
    4. Long J,
    5. Xue R,
    6. Ai N, et al.
    Copy number variation is highly correlated with differential gene expression: a pan-cancer study. BMC Med Genet. 2019; 20: 175.
    OpenUrlCrossRef
  39. 39.↵
    1. Gillette MA,
    2. Satpathy S,
    3. Cao S,
    4. Dhanasekaran SM,
    5. Vasaikar SV,
    6. Krug K, et al.
    Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma. Cell. 2020; 182: 200–25.e35.
    OpenUrlCrossRef
  40. 40.↵
    1. Ben-David U,
    2. Amon A.
    Context is everything: aneuploidy in cancer. Nat Rev Genet. 2020; 21: 44–62.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

Cancer Biology & Medicine: 19 (5)
Cancer Biology & Medicine
Vol. 19, Issue 5
15 May 2022
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Cancer Biology & Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy
(Your Name) has sent you a message from Cancer Biology & Medicine
(Your Name) thought you would like to see the Cancer Biology & Medicine web site.
Citation Tools
Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy
Fan Kou, Lei Wu, Yan Guo, Bailu Zhang, Baihui Li, Ziqi Huang, Xiubao Ren, Lili Yang
Cancer Biology & Medicine May 2022, 19 (5) 685-695; DOI: 10.20892/j.issn.2095-3941.2020.0728

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy
Fan Kou, Lei Wu, Yan Guo, Bailu Zhang, Baihui Li, Ziqi Huang, Xiubao Ren, Lili Yang
Cancer Biology & Medicine May 2022, 19 (5) 685-695; DOI: 10.20892/j.issn.2095-3941.2020.0728
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and methods
    • Results
    • Discussion
    • Conclusions
    • Supporting Information
    • Grant support
    • Conflict of interest statement
    • Author contributions
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Thermal ablation versus loop electrosurgical excision procedure and cold knife conization for cervical intraepithelial neoplasia: efficacy and HPV clearance in a 5-year cohort of Chinese women
  • Bifidobacterium animalis suppresses melanoma progression and activates anti-tumor immunity by inhibiting YAP1 expression in CD8+ T cells
  • Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left- and right-sided colorectal neoplasia
Show more Original Article

Similar Articles

Keywords

  • SCNA
  • radiotherapy
  • Lung cancer
  • progression-free survival
  • immune infiltration

Navigate

  • Home
  • Current Issue

More Information

  • About CBM
  • About CACA
  • About TMUCIH
  • Editorial Board
  • Subscription

For Authors

  • Instructions for authors
  • Journal Policies
  • Submit a Manuscript

Journal Services

  • Email Alerts
  • Facebook
  • RSS Feeds
  • Twitter

 

© 2026 Cancer Biology & Medicine

Powered by HighWire