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Research ArticleOriginal Article

JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ

Zilu Zhang, Chenjing Ye, Jia Liu, Wenbin Xu, Chao Wu, Qing Yu, Xiaoguang Xu, Xinyi Zeng, Huizi Jin, Yingli Wu and Hua Yan
Cancer Biology & Medicine May 2022, 19 (5) 651-668; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0473
Zilu Zhang
1Shanghai Institute of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Chenjing Ye
2VIP Health Center, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Jia Liu
1Shanghai Institute of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Wenbin Xu
2VIP Health Center, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Chao Wu
2VIP Health Center, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Qing Yu
2VIP Health Center, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Xiaoguang Xu
1Shanghai Institute of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Xinyi Zeng
1Shanghai Institute of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Huizi Jin
3Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
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Yingli Wu
4Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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  • For correspondence: [email protected] [email protected]
Hua Yan
1Shanghai Institute of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2VIP Health Center, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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  • For correspondence: [email protected] [email protected]
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Article Information

vol. 19 no. 5 651-668
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0473
PubMed 
34570444

Published By 
Cancer Biology & Medicine
History 
  • Received August 15, 2020
  • Accepted March 10, 2021
  • Published online June 24, 2022.

Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Zilu Zhang1,*,
  2. Chenjing Ye2,*,
  3. Jia Liu1,
  4. Wenbin Xu2,
  5. Chao Wu2,
  6. Qing Yu2,
  7. Xiaoguang Xu1,
  8. Xinyi Zeng1,
  9. Huizi Jin3,
  10. Yingli Wu4⇑ and
  11. Hua Yan1,2⇑
  1. 1Shanghai Institute of Hematology, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  2. 2VIP Health Center, Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  3. 3Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
  4. 4Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  1. Correspondence to: Hua Yan and Yingli Wu, E-mail: yanhua_candy{at}163.com and wuyingli{at}shsmu.edu.cn
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Cancer Biology & Medicine: 19 (5)
Cancer Biology & Medicine
Vol. 19, Issue 5
15 May 2022
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JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ
Zilu Zhang, Chenjing Ye, Jia Liu, Wenbin Xu, Chao Wu, Qing Yu, Xiaoguang Xu, Xinyi Zeng, Huizi Jin, Yingli Wu, Hua Yan
Cancer Biology & Medicine May 2022, 19 (5) 651-668; DOI: 10.20892/j.issn.2095-3941.2020.0473

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JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ
Zilu Zhang, Chenjing Ye, Jia Liu, Wenbin Xu, Chao Wu, Qing Yu, Xiaoguang Xu, Xinyi Zeng, Huizi Jin, Yingli Wu, Hua Yan
Cancer Biology & Medicine May 2022, 19 (5) 651-668; DOI: 10.20892/j.issn.2095-3941.2020.0473
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Keywords

  • Multiple myeloma
  • NF-κB
  • JaponiconeA
  • bortezomib
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