Review ArticleReview
Research progress in hepatitis B virus covalently closed circular DNA
Xiaodong Zhang, Yufei Wang and Guang Yang
Cancer Biology & Medicine April 2022, 19 (4) 415-431; DOI: https://doi.org/10.20892/j.issn.2095-3941.2021.0454
Xiaodong Zhang
1Department of Gastrointestinal Cancer Biology, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
Yufei Wang
2Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China
Guang Yang
1Department of Gastrointestinal Cancer Biology, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China

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In this issue
Research progress in hepatitis B virus covalently closed circular DNA
Xiaodong Zhang, Yufei Wang, Guang Yang
Cancer Biology & Medicine Apr 2022, 19 (4) 415-431; DOI: 10.20892/j.issn.2095-3941.2021.0454
Jump to section
- Article
- Abstract
- Introduction
- Mapping the HBV cccDNA minichromosome
- Regulation and epigenetic modulation of the HBV cccDNA minichromosome
- HBx links the cccDNA minichromosome to hepatocarcinogenesis
- Detection of HBV cccDNA
- IFN and cccDNA
- Therapeutic strategies against cccDNA
- Perspectives
- Conflict of interest statement
- Author contributions
- References
- Figures & Data
- Info & Metrics
- References
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