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Review ArticleReview

Research progress in hepatitis B virus covalently closed circular DNA

Xiaodong Zhang, Yufei Wang and Guang Yang
Cancer Biology & Medicine April 2022, 19 (4) 415-431; DOI: https://doi.org/10.20892/j.issn.2095-3941.2021.0454
Xiaodong Zhang
1Department of Gastrointestinal Cancer Biology, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: [email protected]
Yufei Wang
2Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China
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Guang Yang
1Department of Gastrointestinal Cancer Biology, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Article Information

vol. 19 no. 4 415-431
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2021.0454
PubMed 
34931766

Published By 
Cancer Biology & Medicine
History 
  • Received August 26, 2021
  • Accepted November 16, 2021
  • Published online April 1, 2022.

Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Xiaodong Zhang1⇑,
  2. Yufei Wang2 and
  3. Guang Yang1
  1. 1Department of Gastrointestinal Cancer Biology, Liver Cancer Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
  2. 2Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China
  1. Correspondence to: Xiaodong Zhang, E-mail: zhangxiaodong{at}tjmuch.com
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Cancer Biology & Medicine: 19 (4)
Cancer Biology & Medicine
Vol. 19, Issue 4
15 Apr 2022
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Research progress in hepatitis B virus covalently closed circular DNA
Xiaodong Zhang, Yufei Wang, Guang Yang
Cancer Biology & Medicine Apr 2022, 19 (4) 415-431; DOI: 10.20892/j.issn.2095-3941.2021.0454

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Research progress in hepatitis B virus covalently closed circular DNA
Xiaodong Zhang, Yufei Wang, Guang Yang
Cancer Biology & Medicine Apr 2022, 19 (4) 415-431; DOI: 10.20892/j.issn.2095-3941.2021.0454
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  • Article
    • Abstract
    • Introduction
    • Mapping the HBV cccDNA minichromosome
    • Regulation and epigenetic modulation of the HBV cccDNA minichromosome
    • HBx links the cccDNA minichromosome to hepatocarcinogenesis
    • Detection of HBV cccDNA
    • IFN and cccDNA
    • Therapeutic strategies against cccDNA
    • Perspectives
    • Conflict of interest statement
    • Author contributions
    • References
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  • References
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Keywords

  • Hepatitis B virus
  • cccDNA
  • HBx
  • hepatocarcinogenesis
  • epigenetic modulation
  • therapy

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