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Review ArticleReview

Heterogeneity of neutrophils in cancer: one size does not fit all

Song Chen, Qingyu Zhang, Lisha Lu, Chunhui Xu, Jiajia Li, Jiali Zha, Fengxia Ma, Hongbo R. Luo and Alan Y. Hsu
Cancer Biology & Medicine December 2022, 19 (12) 1629-1648; DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0426
Song Chen
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
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Qingyu Zhang
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
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Lisha Lu
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
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Chunhui Xu
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
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Jiajia Li
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
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Jiali Zha
2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
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Fengxia Ma
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
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Hongbo R. Luo
2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
3Department of Laboratory Medicine, The Stem Cell Program, Boston Children’s Hospital, Boston, MA 02115, USA
4Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA
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  • ORCID record for Hongbo R. Luo
  • For correspondence: Hongbo.Luo{at}childrens.harvard.edu Alan.Hsu{at}childrens.harvard.edu
Alan Y. Hsu
2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
3Department of Laboratory Medicine, The Stem Cell Program, Boston Children’s Hospital, Boston, MA 02115, USA
4Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA
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  • For correspondence: Hongbo.Luo{at}childrens.harvard.edu Alan.Hsu{at}childrens.harvard.edu
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Article Information

vol. 19 no. 12 1629-1648
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2022.0426
PubMed 
36514901

Published By 
Cancer Biology & Medicine
History 
  • Received July 20, 2022
  • Accepted October 13, 2022
  • Published online December 12, 2022.

Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Song Chen1,
  2. Qingyu Zhang1,
  3. Lisha Lu1,
  4. Chunhui Xu1,
  5. Jiajia Li1,
  6. Jiali Zha2,
  7. Fengxia Ma1,
  8. Hongbo R. Luo2,3,4⇑ and
  9. Alan Y. Hsu2,3,4⇑
  1. 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
  2. 2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
  3. 3Department of Laboratory Medicine, The Stem Cell Program, Boston Children’s Hospital, Boston, MA 02115, USA
  4. 4Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA
  1. Correspondence to: Hongbo R. Luo and Alan Y. Hsu, E-mail: Hongbo.Luo{at}childrens.harvard.edu and Alan.Hsu{at}childrens.harvard.edu
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Cancer Biology & Medicine: 19 (12)
Cancer Biology & Medicine
Vol. 19, Issue 12
15 Dec 2022
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Heterogeneity of neutrophils in cancer: one size does not fit all
Song Chen, Qingyu Zhang, Lisha Lu, Chunhui Xu, Jiajia Li, Jiali Zha, Fengxia Ma, Hongbo R. Luo, Alan Y. Hsu
Cancer Biology & Medicine Dec 2022, 19 (12) 1629-1648; DOI: 10.20892/j.issn.2095-3941.2022.0426

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Heterogeneity of neutrophils in cancer: one size does not fit all
Song Chen, Qingyu Zhang, Lisha Lu, Chunhui Xu, Jiajia Li, Jiali Zha, Fengxia Ma, Hongbo R. Luo, Alan Y. Hsu
Cancer Biology & Medicine Dec 2022, 19 (12) 1629-1648; DOI: 10.20892/j.issn.2095-3941.2022.0426
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  • Article
    • Abstract
    • Introduction
    • Neutrophil differentiation, mobilization, and death
    • Neutrophil recruitment in tissues and tumors
    • Neutrophil heterogeneity
    • Pro-tumoral neutrophil functions
    • Neutrophil antitumoral functions
    • Neutrophils in tumor metastasis
    • Conclusion
    • Grant support
    • Conflict of interest statement
    • Author contributions
    • References
  • Figures & Data
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  • References
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Keywords

  • Neutrophils in cancer
  • tumor microenvironment
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  • neutrophil heterogeneity
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