Article Figures & Data
Figures
- Figure 1
Key milestones for GC screening in China. UGCED, Upper Gastrointestinal Cancer Early Detection. CanSPUC, Cancer Screening Program in Urban China.
Tables
- Table 1
Studies on the performance of PG combined with other biomarkers in predicting GC risk
Reference Methods Included biomarkers and factors Risk groups or score ranges AUC Miki 201119 ABC method Hp infection, PG I and PGR (PG I ≤70 ng/mL and PGR ≤3 classified as PG positive) Group A: Hp(−) PG(−)
Group B: Hp(−) PG(+)
Group C: Hp(+) PG(+)
Group D: Hp(−) PG(+)0.527† Tu 201720 Combination of 5 serum biomarkers Hp infection (score of 7 for Hp positive participants)
PGR (score of 4 for PGR ≤ 7)
PGI (score of 1 for PGI < 30 ng/mL)
PGII (score of 0, 1, 3, and 6 for quartiles 1–4, respectively)
G-17 (score of 1, 0, 1, and 3 for quartiles 1–4, respectively)Serum biopsy score, ranging from 0 to 21 0.803* Cai 201921 Combination of 7 indicators Age (score of 4, 6 and 9 for ages 50–59, 60–69 and > 69, respectively)
Sex (score of 4 for males)
Pickled or fried food (score of 2 for regular intake)
Hp infection (score of 1 for Hp positive participants)
PGR (score of 3 for PGR < 3.89)
G-17 (score of 3 for 1.50–5.70 pmol/L and score of 4 for > 5.70 pmol/L)0–25,
Low risk (≤ 11)
Moderate risk (12–16) High risk (17–25)0.757 Shida 202022 ABC method combined with KK-LC-1 Hp infection, PG I, PGR, combining KK-LC-1 expression ABC method, as in Miki 201119 - Zeng 202023 Serum miRNA biomarkers combined with PG miR-101-3p, PG I and PGR Youden index as cutoff value 0.856 Hp, Helicobacter pylori; PG, pepsinogen; PGR, the PGI to PGII ratio; G-17, gastrin-17; KK-LC-1, Kita-Kyushu lung cancer antigen-1. †Evaluated by Cai 201921. *Concordance index.
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