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Review ArticleReview

Targeting PP2A for cancer therapeutic modulation

Halle Ronk, Jared S. Rosenblum, Timothy Kung and Zhengping Zhuang
Cancer Biology & Medicine October 2022, 19 (10) 1428-1439; DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0330
Halle Ronk
1Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
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Jared S. Rosenblum
1Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
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Timothy Kung
1Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
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Zhengping Zhuang
1Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
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  • For correspondence: [email protected]
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Article Information

vol. 19 no. 10 1428-1439
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2022.0330

Published By 
Cancer Biology & Medicine
History 
  • Received June 15, 2022
  • Accepted August 26, 2022
  • Published online November 3, 2022.

Copyright & Usage 
Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Halle Ronk1,
  2. Jared S. Rosenblum1,
  3. Timothy Kung1 and
  4. Zhengping Zhuang1⇑
  1. 1Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
  1. Correspondence to: Zhengping Zhuang, E-mail: zhengping.zhuang{at}nih.gov
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Cancer Biology & Medicine: 19 (10)
Cancer Biology & Medicine
Vol. 19, Issue 10
15 Oct 2022
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Targeting PP2A for cancer therapeutic modulation
Halle Ronk, Jared S. Rosenblum, Timothy Kung, Zhengping Zhuang
Cancer Biology & Medicine Oct 2022, 19 (10) 1428-1439; DOI: 10.20892/j.issn.2095-3941.2022.0330

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Targeting PP2A for cancer therapeutic modulation
Halle Ronk, Jared S. Rosenblum, Timothy Kung, Zhengping Zhuang
Cancer Biology & Medicine Oct 2022, 19 (10) 1428-1439; DOI: 10.20892/j.issn.2095-3941.2022.0330
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  • Article
    • Abstract
    • Introduction
    • LB100: a modulator of immunotherapy
    • Updates: LB100 as a chemo-sensitizer
    • Updates: LB100 as a radio-sensitizer
    • Discussion
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    • Conflict of interest statement
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Keywords

  • Chemo-sensitization
  • clinical trials
  • Colorectal cancer
  • glioblastoma
  • immunotherapy
  • LB100
  • protein phosphatase 2A
  • PP2A inhibition
  • radio-sensitization
  • small molecule inhibitor

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