Research ArticleOriginal Article
Phase II study of apatinib in combination with oral vinorelbine in heavily pretreated HER2-negative metastatic breast cancer and clinical implications of monitoring ctDNA
Anjie Zhu, Peng Yuan, Nanlin Hu, Mingzhou Li, Wenmiao Wang, Xue Wang, Jian Yue, Jiayu Wang, Yang Luo, Fei Ma, Pin Zhang, Qing Li, Binghe Xu, Shanbo Cao, Giuseppe Lippi, Yoichi Naito, Mohammed A. Osman, Gustavo N. Marta, Gianluca Franceschini and Armando Orlandi
Cancer Biology & Medicine August 2021, 18 (3) 875-887; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0418
Anjie Zhu
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China
Peng Yuan
3Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Nanlin Hu
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Mingzhou Li
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Wenmiao Wang
4Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Xue Wang
3Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Jian Yue
3Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Jiayu Wang
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Yang Luo
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Fei Ma
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Pin Zhang
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Qing Li
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Binghe Xu
1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Shanbo Cao
5AcornMed Biotechnology Co., Ltd., Beijing 101102, China
Giuseppe Lippi
6Section of Clinical Biochemistry, University Hospital of Verona, Verona 37100, Italy
Yoichi Naito
7Department of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa 277-8577, Japan
Mohammed A. Osman
8Clinical Oncology, General Organization for Teaching Hospitals, Cairo 11435, Egypt
Gustavo N. Marta
9Department of Radiation Oncology, Hospital Sírio-Libanês, Sao Paulo 01308-050, Brazil
Gianluca Franceschini
10Multidisciplinary Breast Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00176, Italy
Armando Orlandi
11Unit of Medical Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma 00176, Italy
References
- 1.↵
- 2.↵
- Schneider BP,
- Miller KD.
- 3.↵
- 4.↵
- Brufsky AM,
- Hurvitz S,
- Perez E,
- Swamy R,
- Valero V,
- O’Neill V, et al.
- 5.
- Miles DW,
- Chan A,
- Dirix LY,
- Cortés J,
- Pivot X,
- Tomczak P, et al.
- 6.
- Miller K,
- Wang M,
- Gralow J,
- Dickler M,
- Cobleigh M,
- Perez EA, et al.
- 7.
- Bergh J,
- Bondarenko IM,
- Lichinitser MR,
- Liljegren A,
- Greil R,
- Voytko NL, et al.
- 8.
- Crown JP,
- Diéras V,
- Staroslawska E,
- Yardley DA,
- Bachelot T,
- Davidson N, et al.
- 9.
- Gradishar WJ,
- Kaklamani V,
- Sahoo TP,
- Lokanatha D,
- Raina V,
- Bondarde S, et al.
- 10.
- Baselga J,
- Segalla JGM,
- Roché H,
- del Giglio A,
- Pinczowski H,
- Ciruelos EM, et al.
- 11.↵
- Baselga J,
- Zamagni C,
- Gómez P,
- Bermejo B,
- Nagai SE,
- Melichar B, et al.
- 12.↵
- Li J,
- Zhao X,
- Chen L,
- Guo H,
- Lv F,
- Jia K, et al.
- 13.↵
- 14.↵
- Mi Y-J,
- Liang Y-J,
- Huang H-B,
- Zhao H-Y,
- Wu C-P,
- Wang F, et al.
- 15.↵
- 16.↵
- Hu X,
- Cao J,
- Hu W,
- Wu C,
- Pan Y,
- Cai L, et al.
- 17.↵
- 18.↵
- Li Y-H,
- Zhou Y,
- Wang Y-W,
- Tong L,
- Jiang R-X,
- Xiao L, et al.
- 19.
- Hu T,
- Liu C,
- Li Q,
- Xiong J,
- Ma Y,
- Wu G, et al.
- 20.↵
- 21.↵
- Blancas I,
- Morales S,
- Diaz N,
- Barnadas A,
- Gonzalvez M,
- del Barco S, et al.
- 22.
- Freyer G,
- Delozier T,
- Lichinister M,
- Gedouin D,
- Bougnoux P,
- His P, et al.
- 23.
- Winer EP,
- Chu L,
- Spicer DV.
- 24.↵
- Mansour M,
- Mourad C.
- 25.↵
- Delcambre C,
- Veyret C,
- Levy C,
- Switsers O,
- Allouache D,
- Raban N, et al.
- 26.
- Finek J,
- Holubec L,
- Svoboda T,
- Sefrhansova L,
- Pavlikova I,
- Votavova M, et al.
- 27.
- Gil-Delgado M,
- Rocher M,
- Boostandoost E,
- Khayat D.
- 28.
- 29.↵
- 30.↵
- Mavroeidis L,
- Sheldon H,
- Briasoulis E,
- Marselos M,
- Pappas P,
- Harris AL.
- 31.↵
- Klement G,
- Baruchel S,
- Rak J,
- Man S,
- Clark K,
- Hicklin DJ, et al.
- 32.↵
- Li H,
- Sun L,
- Li H,
- Lv X,
- Semukunzi H,
- Li R, et al.
- 33.
- Qin RS,
- Zhang ZH,
- Zhu NP,
- Chen F,
- Guo Q,
- Hu HW, et al.
- 34.
- Tan EH,
- Tan DS,
- Li WY,
- Haaland B,
- Ang MK,
- Chau NM, et al.
- 35.↵
- Tsui KH,
- Wu MY,
- Lin LT,
- Wen ZH,
- Li YH,
- Chu PY, et al.
- 36.↵
- 37.↵
- 38.↵
- 39.↵
- 40.↵
- Olsson E,
- Winter C,
- George A,
- Chen Y,
- Howlin J,
- Tang MHE, et al.
- 41.↵
- Garcia-Murillas I,
- Schiavon G,
- Weigelt B,
- Ng C,
- Hrebien S,
- Cutts RJ, et al.
- 42.↵
- Dawson S-J,
- Tsui DW,
- Murtaza M,
- Biggs H,
- Rueda OM,
- Chin S-F, et al.
- 43.↵
- Murtaza M,
- Dawson S-J,
- Tsui DW,
- Gale D,
- Forshew T,
- Piskorz AM, et al.
- 44.↵
- Murtaza M,
- Dawson S-J,
- Pogrebniak K,
- Rueda OM,
- Provenzano E,
- Grant J, et al.
- 45.↵
- Petrelli F,
- Di Cosimo S,
- Lonati V,
- Barni S.
- 46.↵
- Yuan P,
- Hu X,
- Sun T,
- Li W,
- Zhang Q,
- Cui S, et al.
- 47.↵
- Huang L,
- Wei Y,
- Shen S,
- Shi Q,
- Bai J,
- Li J, et al.
- 48.↵
- Laird BJ,
- Kaasa S,
- McMillan DC,
- Fallon MT,
- Hjermstad MJ,
- Fayers P, et al.
- 49.↵
- Bourgeois H,
- Grudé F,
- Solal-Céligny P,
- Dupuis O,
- Voog E,
- Ganem G, et al.
- 50.↵
- Zimmermann C,
- Swami N,
- Krzyzanowska M,
- Hannon B,
- Leighl N,
- Oza A, et al.
- 51.↵
- Uzzan B,
- Nicolas P,
- Cucherat M,
- Perret G-Y.
- 52.↵
- 53.↵
- Toi M,
- Matsumoto T,
- Bando H.
- 54.↵
- Linderholm B,
- Hellborg H,
- Johansson U,
- Elmberger G,
- Skoog L,
- Lehtiö J, et al.
- 55.↵
- Rossi G,
- Mu Z,
- Rademaker AW,
- Austin LK,
- Strickland KS,
- Costa RLB, et al.
- 56.↵
- Chen X,
- Qiu T,
- Zhu Y,
- Sun J,
- Li P,
- Wang B, et al.
- 57.↵
- Lacal PM,
- Graziani G.
- 58.↵
- Romero-Laorden N,
- Doger B,
- Hernandez M,
- Hernandez C,
- Rodriguez-Moreno J,
- Garcia-Donas J.
- 59.↵
- Schiavon G,
- Hrebien S,
- Garcia-Murillas I,
- Cutts RJ,
- Pearson A,
- Tarazona N, et al.
- 60.
- 61.↵
- Chu D,
- Paoletti C,
- Gersch C,
- VanDenBerg DA,
- Zabransky DJ,
- Cochran RL, et al.
- 62.↵
- Page K,
- Guttery DS,
- Fernandez-Garcia D,
- Hills A,
- Hastings RK,
- Luo J, et al.
- 63.↵
- Liang DH,
- Ensor JE,
- Liu Z-B,
- Patel A,
- Patel TA,
- Chang JC, et al.
- 64.↵
- 65.↵
- 66.↵
- Levitzki A.
- 67.
- Fletcher JA.
- 68.↵
- Blume-Jensen P,
- Hunter T.
- 69.↵
- Bergers G,
- Song S,
- Meyer-Morse N,
- Bergsland E,
- Hanahan D.
- 70.↵
In this issue
Phase II study of apatinib in combination with oral vinorelbine in heavily pretreated HER2-negative metastatic breast cancer and clinical implications of monitoring ctDNA
Anjie Zhu, Peng Yuan, Nanlin Hu, Mingzhou Li, Wenmiao Wang, Xue Wang, Jian Yue, Jiayu Wang, Yang Luo, Fei Ma, Pin Zhang, Qing Li, Binghe Xu, Shanbo Cao, Giuseppe Lippi, Yoichi Naito, Mohammed A. Osman, Gustavo N. Marta, Gianluca Franceschini, Armando Orlandi
Cancer Biology & Medicine Aug 2021, 18 (3) 875-887; DOI: 10.20892/j.issn.2095-3941.2020.0418
Phase II study of apatinib in combination with oral vinorelbine in heavily pretreated HER2-negative metastatic breast cancer and clinical implications of monitoring ctDNA
Anjie Zhu, Peng Yuan, Nanlin Hu, Mingzhou Li, Wenmiao Wang, Xue Wang, Jian Yue, Jiayu Wang, Yang Luo, Fei Ma, Pin Zhang, Qing Li, Binghe Xu, Shanbo Cao, Giuseppe Lippi, Yoichi Naito, Mohammed A. Osman, Gustavo N. Marta, Gianluca Franceschini, Armando Orlandi
Cancer Biology & Medicine Aug 2021, 18 (3) 875-887; DOI: 10.20892/j.issn.2095-3941.2020.0418
Jump to section
Related Articles
- No related articles found.