Article Figures & Data
Figures
- Figure 1
Kaplan-Meier curves of 6 systems which all showed overlapping survival curves. (A) Kaplan-Meier curves of the Barcelona Clinic Liver Cancer staging. (B) Kaplan-Meier curves of the TNM staging. (C) Kaplan-Meier curves of the CLIP. (D) Kaplan-Meier curves of the JIS. (E) Kaplan-Meier curves of the Ueda classification system. (F) Kaplan-Meier curves of the Japanese B-classification system. All 6 systems showed overlapping survival curves.
- Figure 2
Patterns of biliary tumor thrombus type systems. T: hepatic tumor.
- Figure 3
Overall survival according to different biliary tumor thrombus types. (A) The median OS of type I and type II. (B) The median DFS of type I and type II.
- Figure 4
Kaplan-Meier curves of the subtypes of the new biliary tumor thrombus types. (A) The median OS of type Ia and type Ib. (B) The median OS of type IIa and type IIb.
Tables
Current model n 1-year survival 3-year survival 5-year survival P TNM 0.097 1 112 75.0% 28.6% 9.8% 2 18 77.8% 44.4% 11.1% 3 70 75.7% 24.3% 10.0% 4 2 50.0% 0 0 JIS score 0.002 0 9 88.9% 0 0 1 88 83.0% 35.2% 12.5% 2 71 71.8% 26.8% 9.9% 3 32 59.4% 21.9% 3.1% 4 2 50.0% 0 0 CLIP score 0.497 0 37 97.3% 30.6% 13.5% 1 86 68.6% 37.3% 10.5% 2 44 75.0% 48.5% 9.1% 3 30 70.0% 33.3% 3.3% 4 5 60.0% 33.3% 0 BCLC stage 0.375 A 65 72.3% 35.4% 10.8% B 99 78.8% 25.3% 9.1% C 38 71.1% 23.7% 7.9% B-classification 0.009 1 10 100.0% 20.0% 10.0% 2 25 96.0% 52.0% 32.0% 3 34 82.4% 32.4% 23.5% 4 133 67.7% 23.3% 1.5% Ueda-classification 0.001 1 35 97.1% 42.9% 25.7% 2 34 82.4% 32.4% 23.5% 3 124 69.4% 25.0% 1.6% 4 5 20.0% 0 0 5 4 25.0% 0 0 Variable Univariate analysis Multivariate analysis β 95%CI P β 95%CI P Age (years) < 50 0.003 1.003 (0.714–1.409) 0.085 Gender (N), male: female 0.131 1.140 (0.710–1.829) 0.589 AFP (μg/L), < 400: ≥ 400 −0.195 0.823 (0.589–1.150) 0.254 ALT (U/L), < 40: ≥ 40 −0.025 0.976 (0.674–1.413) 0.897 Total bilirubin (μmol/L) > 300 0.905 2.472 (1.461–4.183) 0.001 0.73 2.075 (1.210–3.559) 0.008 Hbs Ag (N), positive: negative 0.079 1.082 (0.681–1.721) 0.738 HBV-DNA (copies/mL) < 1,000 0.124 1.122 (0.764–1.680) 0.536 Tumor number, single 0.055 1.056 (0.740–1.508) 0.764 Tumor diameter, < 5 cm −0.039 0.962 (0.686–1.348) 0.821 Coexistence of PVTT 0.378 1.460 (0.983–2.167) 0.061 Child-Pugh A:B 0.434 1.543 (1.106–2.154) 0.011 0.066 1.068 (0.700–1.631) 0.759 ALP < 135 U/L 0.215 1.240 (0.870–1.766) 0.234 GGT < 45 U/L 1.28 3.596 (0.887–14.576) 0.073 PT < 13 S 0.207 1.230 (0.857–1.766) 0.261 BDTT, Intrahepatic: extrahepatic 0.555 1.743 (1.207–2.516) 0.003 0.47 1.600 (1.097–2.332) 0.015 Anatomic: local resection 0.32 1.377 (0.989–1.918) 0.058 - Table 3
The clinicopathological features of the 2 types of biliary tumor thrombus patients
Variable Type I (n = 69) Type II (n = 133) P Age 51.3 ± 11.0 52.9 ± 10.2 0.512 Gender (N), male:female 53/16 117/16 0.039 AFP (μg/L), < 400: ≥ 400 33/36 76/57 0.208 ALT (U/L), < 40: ≥ 40 30/39 23/110 0.001 Total bilirubin (μmol/L) 25.97 ± 44.1 135.3 ± 123.9 0.001 ALP (U/L) 147.9 ± 73.0 262.5 ± 153.1 0.001 PT (S) 12.1 ± 1.0 12.5 ± 1.3 0.079 Hbs Ag (N), positive: negative 62/7 111/22 0.219 HBV-DNA (copies/mL) 0.479 < 1,000 52 106 ≥ 1,000 17 27 Tumor number, single: multiple 45/24 93/40 0.495 Tumor diameter (cm) 7.34 ± 5.08 5.52 ± 3.35 0.052 Coexistence of PVTT (n) 18/69 23/133 0.148 Child-Pugh A:B 65/4 52/81 0.001 Anatomic/local resection 41/28 63/70 0.104 Types Type I: intrahepatic BTT P Type II: extrahepatic BTT P Subtypes Type Ia: tumor thrombosis involving the second-order intrahepatic duct or above Type Ib: tumor thrombosis involving the first-order intrahepatic duct Type IIa: TB < 300 μmol/L Type IIb: TB > 300 μmol/L OS (%) 0.070 0.023 1-year 97.1% 82.4% 68.4% 62.5% 3-year 42.9% 32.4% 24.8% 12.5% OS (month) 44.4 30.4 23.9 17.4
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