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Research ArticleOriginal Article

Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids

Lisi Zeng, Quanxing Liao, Haoran Zhao, Shengwei Jiang, Xianzi Yang, Hongsheng Tang, Qingjun He, Xiansheng Yang, Shuxian Fang, Jinfu He, Weiwen Cui, Laiqiang Huang, Shaohua Ma and Shuzhong Cui
Cancer Biology & Medicine August 2021, 18 (3) 750-762; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0566
Lisi Zeng
1Institute of Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Quanxing Liao
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Haoran Zhao
3Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
4Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China
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Shengwei Jiang
3Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
4Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China
5Shenzhen Key Laboratory of Gene and Antibody Therapy, Tsinghua University, Shenzhen 518055, China
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  • ORCID record for Shengwei Jiang
  • For correspondence: cuishuzhong{at}gzhmu.edu.cn jiangcw17{at}mails.tsinghua.edu.cn
Xianzi Yang
6Department of Medical Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Hongsheng Tang
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Qingjun He
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Xiansheng Yang
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Shuxian Fang
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Jinfu He
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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Weiwen Cui
7Department of Bioengineering, University of California, Berkeley 94720, USA
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Laiqiang Huang
3Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
4Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China
5Shenzhen Key Laboratory of Gene and Antibody Therapy, Tsinghua University, Shenzhen 518055, China
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Shaohua Ma
3Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
4Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China
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Shuzhong Cui
2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
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  • For correspondence: cuishuzhong{at}gzhmu.edu.cn jiangcw17{at}mails.tsinghua.edu.cn
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Article Information

vol. 18 no. 3 750-762
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0566

Published By 
Cancer Biology & Medicine
History 
  • Received September 17, 2020
  • Accepted November 26, 2020
  • Published online August 1, 2021.

Copyright & Usage 
Copyright: © 2021, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Lisi Zeng1,*,
  2. Quanxing Liao2,*,
  3. Haoran Zhao3,4,
  4. Shengwei Jiang3,4,5⇑,
  5. Xianzi Yang6,
  6. Hongsheng Tang2,
  7. Qingjun He2,
  8. Xiansheng Yang2,
  9. Shuxian Fang2,
  10. Jinfu He2,
  11. Weiwen Cui7,
  12. Laiqiang Huang3,4,5,
  13. Shaohua Ma3,4 and
  14. Shuzhong Cui2⇑
  1. 1Institute of Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
  2. 2Department of Abdominal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
  3. 3Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
  4. 4Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China
  5. 5Shenzhen Key Laboratory of Gene and Antibody Therapy, Tsinghua University, Shenzhen 518055, China
  6. 6Department of Medical Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
  7. 7Department of Bioengineering, University of California, Berkeley 94720, USA
  1. Correspondence to: Shuzhong Cui and Shengwei Jiang, E-mail: cuishuzhong{at}gzhmu.edu.cn and jiangcw17{at}mails.tsinghua.edu.cn
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Cancer Biology and Medicine: 18 (3)
Cancer Biology & Medicine
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Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids
Lisi Zeng, Quanxing Liao, Haoran Zhao, Shengwei Jiang, Xianzi Yang, Hongsheng Tang, Qingjun He, Xiansheng Yang, Shuxian Fang, Jinfu He, Weiwen Cui, Laiqiang Huang, Shaohua Ma, Shuzhong Cui
Cancer Biology & Medicine Aug 2021, 18 (3) 750-762; DOI: 10.20892/j.issn.2095-3941.2020.0566

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Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids
Lisi Zeng, Quanxing Liao, Haoran Zhao, Shengwei Jiang, Xianzi Yang, Hongsheng Tang, Qingjun He, Xiansheng Yang, Shuxian Fang, Jinfu He, Weiwen Cui, Laiqiang Huang, Shaohua Ma, Shuzhong Cui
Cancer Biology & Medicine Aug 2021, 18 (3) 750-762; DOI: 10.20892/j.issn.2095-3941.2020.0566
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Keywords

  • colorectal cancer
  • Organoids
  • hyperthermia chemotherapy sensitization enhancement ratio
  • raltitrexed

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