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Research ArticleOriginal Article

Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy

Ting Zhang, Xinrui Yang, Wanping Xu, Jing Wang, Dawei Wu, Zhixian Hong, Shengxian Yuan, Zhen Zeng, Xiaodong Jia, Shanshan Lu, Rifaat Safadi, Sen Han, Zhihong Yang, Leonard M. Neckers, Suthat Liangpunsakul, Weiping Zhou and Yinying Lu
Cancer Biology & Medicine August 2021, 18 (3) 693-704; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0262
Ting Zhang
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
2Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
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Xinrui Yang
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
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Wanping Xu
3Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, Bethesda 20814, USA
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Jing Wang
4State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100039, China
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Dawei Wu
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
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Zhixian Hong
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
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Shengxian Yuan
5The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
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Zhen Zeng
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
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Xiaodong Jia
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
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Shanshan Lu
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
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Rifaat Safadi
6Hadassah Medical Organization, Hadassah Hebrew University Medical Center, Jerusalem 9112001, Israel
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Sen Han
2Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
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Zhihong Yang
2Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
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Leonard M. Neckers
4State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100039, China
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Suthat Liangpunsakul
2Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
7Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, USA
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Weiping Zhou
5The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
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  • For correspondence: [email protected] [email protected]
Yinying Lu
1Department of the Fifth Medical Center, General Hospital of PLA, Beijing 100039, China
8Center for Synthetic and Systems Biology (CSSB), Tsinghua University, Beijing 100085, China
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  • For correspondence: [email protected] [email protected]
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Cancer Biology and Medicine: 18 (3)
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Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy
Ting Zhang, Xinrui Yang, Wanping Xu, Jing Wang, Dawei Wu, Zhixian Hong, Shengxian Yuan, Zhen Zeng, Xiaodong Jia, Shanshan Lu, Rifaat Safadi, Sen Han, Zhihong Yang, Leonard M. Neckers, Suthat Liangpunsakul, Weiping Zhou, Yinying Lu
Cancer Biology & Medicine Aug 2021, 18 (3) 693-704; DOI: 10.20892/j.issn.2095-3941.2020.0262

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Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy
Ting Zhang, Xinrui Yang, Wanping Xu, Jing Wang, Dawei Wu, Zhixian Hong, Shengxian Yuan, Zhen Zeng, Xiaodong Jia, Shanshan Lu, Rifaat Safadi, Sen Han, Zhihong Yang, Leonard M. Neckers, Suthat Liangpunsakul, Weiping Zhou, Yinying Lu
Cancer Biology & Medicine Aug 2021, 18 (3) 693-704; DOI: 10.20892/j.issn.2095-3941.2020.0262
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Keywords

  • hepatocellular carcinoma
  • heat shock protein 90
  • RNA helicase DDX5
  • autophagy
  • β-catenin pathway

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