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Research ArticleOriginal Article

FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma

Tao Chen, Fei Wang, Shupei Wei, Yingjie Nie, Xiaotao Zheng, Yu Deng, Xubin Zhu, Yuezhen Deng, Nanshan Zhong and Chengzhi Zhou
Cancer Biology & Medicine August 2021, 18 (3) 665-674; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0389
Tao Chen
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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Fei Wang
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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Shupei Wei
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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Yingjie Nie
2NHC Key Laboratory of Pulmonary Immunological Diseases, Clinical Research Lab Center, Guizhou Provincial People’s Hospital, Guiyang OK 550002, China
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Xiaotao Zheng
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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Yu Deng
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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Xubin Zhu
3Longgang Central Hospital of Shenzhen, Affiliated Shenzhen Longgang Central Hospital of Zunyi Medical College, Shenzhen 518116, China
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Yuezhen Deng
4Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha 410078, China
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Nanshan Zhong
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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Chengzhi Zhou
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
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  • ORCID record for Chengzhi Zhou
  • For correspondence: doctorzcz{at}163.com
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Article Information

vol. 18 no. 3 665-674
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0389

Published By 
Cancer Biology & Medicine
History 
  • Received September 16, 2020
  • Accepted December 23, 2020
  • Published online August 1, 2021.

Copyright & Usage 
Copyright: © 2021, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Tao Chen1,*,
  2. Fei Wang1,*,
  3. Shupei Wei1,
  4. Yingjie Nie2,
  5. Xiaotao Zheng1,
  6. Yu Deng1,
  7. Xubin Zhu3,
  8. Yuezhen Deng4,
  9. Nanshan Zhong1 and
  10. Chengzhi Zhou1⇑
  1. 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
  2. 2NHC Key Laboratory of Pulmonary Immunological Diseases, Clinical Research Lab Center, Guizhou Provincial People’s Hospital, Guiyang OK 550002, China
  3. 3Longgang Central Hospital of Shenzhen, Affiliated Shenzhen Longgang Central Hospital of Zunyi Medical College, Shenzhen 518116, China
  4. 4Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha 410078, China
  1. Correspondence To: Chengzhi Zhou, E-mail: doctorzcz{at}163.com
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Cancer Biology and Medicine: 18 (3)
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FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma
Tao Chen, Fei Wang, Shupei Wei, Yingjie Nie, Xiaotao Zheng, Yu Deng, Xubin Zhu, Yuezhen Deng, Nanshan Zhong, Chengzhi Zhou
Cancer Biology & Medicine Aug 2021, 18 (3) 665-674; DOI: 10.20892/j.issn.2095-3941.2020.0389

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FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma
Tao Chen, Fei Wang, Shupei Wei, Yingjie Nie, Xiaotao Zheng, Yu Deng, Xubin Zhu, Yuezhen Deng, Nanshan Zhong, Chengzhi Zhou
Cancer Biology & Medicine Aug 2021, 18 (3) 665-674; DOI: 10.20892/j.issn.2095-3941.2020.0389
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Keywords

  • FGFR
  • RACK1
  • MDM2
  • p53
  • senescence

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