Research ArticleOriginal Article

LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA

Mingwei Chen, Xuedong Wei, Xiu Shi, Le Lu, Guangbo Zhang, Yuhua Huang and Jianquan Hou
Cancer Biology & Medicine May 2021, 18 (2) 587-603; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0209

References

  1. 1.↵
    2. Barthel FP,
    3. Johnson KC,
    4. Varn FS,
    5. Moskalik AD,
    6. Tanner G,
    7. Kocakavuk E, et al.
    Longitudinal molecular trajectories of diffuse glioma in adults. Nature. 2019; 576: 112–20.
    OpenUrlCrossRef
  2. 2.↵
    2. Moreno-Rubio J,
    3. Ponce S,
    4. Álvarez R,
    5. Olmedo ME,
    6. Falagan S,
    7. Mielgo X, et al.
    Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer. Cancer Biol Med. 2020; 17: 444–57.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    2. Yan C,
    3. Chang J,
    4. Song X,
    5. Yan F,
    6. Yu W,
    7. An Y, et al.
    Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients. Cancer Biol Med. 2019; 16: 109–24.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    2. Rose KM,
    3. Navaratnam AK,
    4. Faraj KS,
    5. Abdul-Muhsin HM,
    6. Syal A,
    7. Elias L, et al.
    Comparison of open and robot assisted radical nephrectomy with level I and II inferior vena cava tumor thrombus: the mayo clinic experience. Urology. 2020; 136: 152–7.
    OpenUrl
  5. 5.
    2. Clark DJ,
    3. Dhanasekaran SM,
    4. Petralia F,
    5. Pan J,
    6. Song X,
    7. Hu Y, et al.
    Integrated proteogenomic characterization of clear cell renal cell carcinoma. Cell. 2020; 180: 207.
    OpenUrlCrossRefPubMed
  6. 6.
    2. Zhu H,
    3. Wang S,
    4. Shen H,
    5. Zheng X,
    6. Xu X.
    SP1/AKT/FOXO3 signaling is involved in miR-362-3p-mediated inhibition of cell-cycle pathway and EMT progression in renal cell carcinoma. Front Cell Dev Biol. 2020; 8: 297.
    OpenUrl
  7. 7.
    2. Gargalionis AN,
    3. Sarlani E,
    4. Stofas A,
    5. Malakou LS,
    6. Adamopoulos C,
    7. Bamias A, et al.
    Polycystin-1 induces activation of the PI3K/AKT/mTOR pathway and promotes angiogenesis in renal cell carcinoma. Cancer Lett. 2020; 489: 135–43.
    OpenUrl
  8. 8.
    2. Miao D,
    3. Margolis CA,
    4. Gao W,
    5. Voss MH,
    6. Li W,
    7. Martini DJ, et al.
    Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science. 2018; 359: 801–6.
    OpenUrlAbstract/FREE Full Text
  9. 9.
    2. He A,
    3. He S,
    4. Huang C,
    5. Chen Z,
    6. Wu Y,
    7. Gong Y, et al.
    MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition. Aging (Albany NY). 2020; 12: 1465–87.
    OpenUrl
  10. 10.
    2. Chow PM,
    3. Liu SH,
    4. Chang YW,
    5. Kuo KL,
    6. Lin WC,
    7. Huang KH.
    The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma. Cancer Lett. 2020; 471: 27–37.
    OpenUrl
  11. 11.↵
    2. Hamilton MJ,
    3. Young M,
    4. Jang K,
    5. Sauer S,
    6. Neang VE,
    7. King AT, et al.
    HOTAIRM1 lncRNA is downregulated in clear cell renal cell carcinoma and inhibits the hypoxia pathway. Cancer Lett. 2020; 472: 50–8.
    OpenUrl
  12. 12.↵
    2. Wang C,
    3. Chen Y,
    4. Chen K,
    5. Zhang L.
    Long noncoding RNA LINC01134 promotes hepatocellular carcinoma metastasis via activating AKT1S1 and NF-κB signaling. Front Cell Dev Biol. 2020; 8: 429.
    OpenUrl
  13. 13.
    2. Chen Y,
    3. Du H,
    4. Bao L.
    LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214. Cancer Biol Med. 2018; 15: 238–50.
    OpenUrlAbstract/FREE Full Text
  14. 14.
    2. Gong T,
    3. Li Y,
    4. Feng L,
    5. Fang M,
    6. Dai G,
    7. Huang X, et al.
    CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6. Aging (Albany NY). 2020; 12: 12086–106.
    OpenUrl
  15. 15.
    2. Cho SW,
    3. Xu J,
    4. Sun R,
    5. Mumbach MR,
    6. Carter AC,
    7. Chen YG, et al.
    Promoter of lncRNA Gene HIF1A-AS2 is a tumor-suppressor DNA boundary element. Cell. 2018; 173: 1398–412.e22.
    OpenUrlCrossRefPubMed
  16. 16.
    2. Lü G,
    3. Li L,
    4. Wang B,
    5. Kuang L.
    LINC00623/miR-101/HRAS axis modulates IL-1 β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes. Aging (Albany NY). 2020; 12: 3218–37.
    OpenUrl
  17. 17.↵
    2. Chu Y,
    3. Liu Z,
    4. Liu J,
    5. Yu L,
    6. Zhang D,
    7. Pei F.
    Characterization of lncRNA-perturbed TLR-signaling network identifies novel lncRNA prognostic biomarkers in colorectal cancer. Front Cell Dev Biol. 2020; 8: 503.
    OpenUrl
  18. 18.↵
    2. Yu X,
    3. Ye X,
    4. Lin H,
    5. Feng N,
    6. Gao S,
    7. Zhang X, et al.
    Knockdown of long non-coding RNA inhibits autophagy in lung cancer. Cancer Biol Med. 2018; 15: 228–37.
    OpenUrlAbstract/FREE Full Text
  19. 19.
    2. Jackson R,
    3. Kroehling L,
    4. Khitun A,
    5. Bailis W,
    6. Jarret A,
    7. York AG, et al.
    The translation of non-canonical open reading frames controls mucosal immunity. Nature. 2018; 564: 434–8.
    OpenUrl
  20. 20.
    2. Li J,
    3. Zhuang C,
    4. Liu Y,
    5. Chen M,
    6. Chen Y,
    7. Chen Z, et al.
    Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer. J Exp Clin Cancer Res. 2016; 35: 99.
    OpenUrl
  21. 21.
    2. Xu J,
    3. Lu Y,
    4. Liu Q,
    5. Xia A,
    6. Zhao J,
    7. Xu X, et al.
    Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B. Cancer Lett. 2020; 473: 1–12.
    OpenUrl
  22. 22.↵
    2. Sarropoulos I,
    3. Marin R,
    4. Cardoso-Moreira M.
    Developmental dynamics of lncRNAs across mammalian organs and species. Nature. 2019; 571: 510–4.
    OpenUrl
  23. 23.↵
    2. Zhang M,
    3. Tang M,
    4. Wu Q,
    5. Wang Z,
    6. Chen Z,
    7. Ding H, et al.
    LncRNA DANCR attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through regulating of miR-33a-5p/XBP1s. Aging (Albany NY). 2020; 12: 1778–91.
    OpenUrl
  24. 24.
    2. Qi Y,
    3. Wu H,
    4. Mai C,
    5. Lin H,
    6. Shen J,
    7. Zhang X, et al.
    LncRNA-MIAT-mediated miR-214-3p silencing is responsible for IL-17 production and cardiac fibrosis in diabetic cardiomyopathy. Front Cell Dev Biol. 2020; 8: 243.
    OpenUrl
  25. 25.
    2. Feng Y,
    3. Hu S,
    4. Li L,
    5. Zhang S,
    6. Liu J,
    7. Xu X, et al.
    LncRNA NR-104098 inhibits AML proliferation and induces differentiation through repressing EZH2 transcription by interacting with E2F1. Front Cell Dev Biol. 2020; 8: 142.
    OpenUrl
  26. 26.
    2. Peng PH,
    3. Chieh-Yu Lai J,
    4. Hsu KW,
    5. Wu KJ.
    Hypoxia-induced lncRNA RP11-390F4.3 promotes epithelial-mesenchymal transition (EMT) and metastasis through upregulating EMT regulators. Cancer Lett. 2020; 483: 35–45.
    OpenUrl
  27. 27.
    2. Chen M,
    3. Li J,
    4. Zhuang C.
    Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer. Oncotarget. 2017; 8: 28176–86.
    OpenUrlPubMed
  28. 28.↵
    2. Zhang W,
    3. Liu Y,
    4. Fu Y,
    5. Han W,
    6. Xu H,
    7. Wen L, et al.
    Long non-coding RNA LINC00160 functions as a decoy of microRNA-132 to mediate autophagy and drug resistance in hepatocellular carcinoma via inhibition of PIK3R3. Cancer Lett. 2020; 478: 22–33.
    OpenUrl
  29. 29.↵
    2. Chen WM,
    3. Huang MD,
    4. Kong R,
    5. Xu TP,
    6. Zhang EB,
    7. Xia R, et al.
    Antisense long noncoding RNA HIF1A-AS2 is upregulated in gastric cancer and associated with poor prognosis. Dig Dis Sci. 2015; 60: 1655–62.
    OpenUrlCrossRefPubMed
  30. 30.↵
    2. Jiang YZ,
    3. Liu YR,
    4. Xu XE,
    5. Jin X,
    6. Hu X,
    7. Yu KD, et al.
    Transcriptome analysis of triple-negative breast cancer reveals an integrated mRNA-lncRNA signature with predictive and prognostic value. Cancer Res. 2016; 76: 2105–14.
    OpenUrlAbstract/FREE Full Text
  31. 31.↵
    2. Guo X,
    3. Lee S.
    The inhibitive effect of sh-HIF1A-AS2 on the proliferation, invasion, and pathological damage of breast cancer via targeting miR-548c-3p through regulating HIF-1α/VEGF pathway in vitro and vivo. Onco Targets Ther. 2019; 12: 825–34.
    OpenUrl
  32. 32.
    2. Liu M,
    3. Xing LQ,
    4. Liu YJ.
    A three-long noncoding RNA signature as a diagnostic biomarker for differentiating between triple-negative and non-triple-negative breast cancers. Medicine. 2017; 96: e6222.
  33. 33.↵
    2. Wang Y,
    3. Zhang G.
    HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer. J Cell Biochem. 2019; 120: 10513–8.
    OpenUrl
  34. 34.↵
    2. Chen M,
    3. Zhuang C,
    4. Liu Y,
    5. Li J,
    6. Dai F,
    7. Xia M, et al.
    Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer. Cancer Lett. 2016; 376: 155–64.
    OpenUrl
  35. 35.↵
    2. Chen X,
    3. Liu M,
    4. Meng F,
    5. Sun B,
    6. Jin X,
    7. Jia C, et al.
    The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancer. J Cell Biochem. 2019; 120: 243–52.
    OpenUrl
  36. 36.↵
    2. Mineo M,
    3. Ricklefs F,
    4. Rooj AK,
    5. Lyons SM,
    6. Ivanov P,
    7. Ansari KI, et al.
    The long non-coding RNA HIF1A-AS2 facilitates the maintenance of mesenchymal glioblastoma stem-like cells in hypoxic niches. J Cell Rep. 2016; 15: 2500–9.
    OpenUrl
  37. 37.↵
    2. Lin J,
    3. Shi Z,
    4. Yu Z.
    LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A. Biomed Pharmacother. 2018; 98: 433–9.
    OpenUrlCrossRef
  38. 38.↵
    2. Wu R,
    3. Ruan J,
    4. Sun Y,
    5. Liu M,
    6. Sha Z,
    7. Fan C, et al.
    Long non-coding RNA HIF1A-AS2 facilitates adipose-derived stem cells (ASCs) osteogenic differentiation through miR-665/IL6 axis via PI3K/Akt signaling pathway. Stem Cell Res Ther. 2018; 9: 348.
    OpenUrl
  39. 39.↵
    2. Zhang Y,
    3. Zhang L,
    4. Wang Y,
    5. Ding H,
    6. Xue S,
    7. Yu H, et al.
    KCNQ1OT1, HIF1A-AS2 and APOA1-AS are promising novel biomarkers for diagnosis of coronary artery disease. Clin Exp Pharmacol Physiol. 2019; 46: 635–42.
    OpenUrl
  40. 40.↵
    2. Wu D,
    3. Yang N,
    4. Xu Y,
    5. Wang S,
    6. Zhang Y,
    7. Sagnelli M, et al.
    lncRNA HIF1A antisense RNA 2 modulates trophoblast cell invasion and proliferation through upregulating PHLDA1 expression. Mol Ther Nucleic Acids. 2019; 16: 605–15.
    OpenUrlCrossRefPubMed
  41. 41.↵
    2. Lin H,
    3. Zhao Z,
    4. Hao Y,
    5. He J,
    6. He J.
    Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma. Biochem Cell Biol. 2020; 98: 284–92.
    OpenUrl
  42. 42.↵
    2. Zhang JW,
    3. Wang X,
    4. Li GC,
    5. Wang D,
    6. Han S,
    7. Zhang YD, et al.
    MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3. J Cancer. 2020; 11: 3604–14.
    OpenUrl
  43. 43.↵
    2. Zhang Y,
    3. Ma L,
    4. Wang C,
    5. Wang L,
    6. Guo Y,
    7. Wang G.
    Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5p. Aging (Albany NY). 2020; 12: 4111–23.
    OpenUrl
  44. 44.↵
    2. Li X,
    3. Liu J,
    4. Liu M,
    5. Xia C,
    6. Zhao Q.
    The Lnc LINC00461/miR-30a-5p facilitates progression and malignancy in non-small cell lung cancer via regulating ZEB2. Cell Cycle. 2020; 19: 825–36.
    OpenUrl
  45. 45.↵
    2. Li J,
    3. Xu X,
    4. Wei C,
    5. Liu L,
    6. Wang T.
    Long noncoding RNA NORAD regulates lung cancer cell proliferation, apoptosis, migration, and invasion by the miR-30a-5p/ADAM19 axis. Int J Clin Exp Pathol. 2020; 13: 1–13.
    OpenUrl
  46. 46.↵
    2. Wu W,
    3. Zhao Y,
    4. Gao E,
    5. Li Y,
    6. Guo X,
    7. Zhao T, et al.
    LncRNA DLEU2 accelerates the tumorigenesis and invasion of non-small cell lung cancer by sponging miR-30a-5p. J Cell Mol Med. 2020; 24: 441–50.
    OpenUrl
  47. 47.↵
    2. Tang M,
    3. Zhou J,
    4. You L,
    5. Cui Z,
    6. Zhang H.
    LIN28B/IRS1 axis is targeted by miR-30a-5p and promotes tumor growth in colorectal cancer. J Cell Biochem. 2020; 121: 3720–9.
    OpenUrl
  48. 48.↵
    2. Li J,
    3. Zhao LM,
    4. Zhang C,
    5. Li M,
    6. Gao B,
    7. Hu XH, et al.
    The lncRNA FEZF1-AS1 Promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p. Oncol Res. 2020; 28: 51–63.
    OpenUrl
  49. 49.↵
    2. Saleh AD,
    3. Cheng H,
    4. Martin SE,
    5. Si H,
    6. Ormanoglu P,
    7. Carlson S, et al.
    Integrated genomic and functional microRNA analysis identifies miR-30-5p as a tumor suppressor and potential therapeutic nanomedicine in head and neck cancer. Clin Cancer Res. 2019; 25: 2860–73.
    OpenUrlAbstract/FREE Full Text
  50. 50.↵
    2. Han C,
    3. Xu B,
    4. Zhou L,
    5. Li L,
    6. Lu C,
    7. Yu GP, et al.
    LINC02738 Participates in the Development of Kidney Cancer Through the miR-20b/Sox4 Axis. Onco Targets Ther. 2020; 13: 10185–96.
    OpenUrl
  51. 51.↵
    2. Liu L,
    3. Yan Y,
    4. Zhang G,
    5. Chen C,
    6. Shen W,
    7. Xing P, et al.
    Knockdown of LINC01694 inhibits growth of gallbladder cancer cells via miR-340-5p/Sox4. Biosci Rep. 2020; 40: BSR20194444.
  52. 52.↵
    2. Ying X,
    3. Zhang W,
    4. Fang M,
    5. Wang C,
    6. Han L,
    7. Yang C.
    LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia. Inflamm Res. 2020; 69: 607–18.
    OpenUrl
  53. 53.↵
    2. Zhang J,
    3. Zhang K,
    4. Hou Y.
    Long non-coding RNA NNT-AS1 knockdown represses the progression of gastric cancer via modulating the miR-142-5p/SOX4/Wnt/β-catenin signaling pathway. Mol Med Rep. 2020; 22: 687–96.
    OpenUrl
  54. 54.↵
    2. Chen H,
    3. Liu T,
    4. Ouyang H,
    5. Lin S,
    6. Zhong H,
    7. Zhang H, et al.
    Upregulation of FTX Promotes Osteosarcoma Tumorigenesis by Increasing SOX4 Expression via miR-214-5p. Onco Targets Ther. 2020; 13: 7125–36.
    OpenUrl
  55. 55.↵
    2. Zhao J,
    3. Bai X,
    4. Feng C,
    5. Shang X,
    6. Xi Y.
    Long non-coding RNA HCP5 facilitates cell invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by miR-140-5p/SOX4 axis. Cancer Manag Res. 2019; 11: 10455–62.
    OpenUrl
  56. 56.↵
    2. Li L,
    3. Wang M,
    4. Mei Z,
    5. Cao W,
    6. Yang Y,
    7. Wang Y, et al.
    LncRNAs HIF1A-AS2 facilitates the up-regulation of HIF-1α by sponging to miR-153-3p, whereby promoting angiogenesis in HUVECs in hypoxia. Biomed Pharmacother. 2017; 96: 165–72.
    OpenUrlCrossRefPubMed
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