Table of Contents

Original Article

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  BRCA mutation rate and characteristics of prostate tumor in breast and ovarian cancer families: analysis of 6,591 Italian pedigrees

  Laura Cortesi, Federica Domati, Annalisa Guida, Isabella Marchi, Angela Toss, Elena Barbieri, Luigi Marcheselli, Marta Venturelli, Simonetta Piana, Claudia Cirilli and Massimo Federico

  Cancer Biology & Medicine May 2021, 18 (2) 470-476; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0481
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  sLe^x expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator

  Yawen Song, Hui Sun, Kailiang Wu, Jianke Lyu, Jingyue Zhang, Feng Gu, Yongjie Ma, Beibei Shen, Chijuan Wang, Xiaojiao Chen, Jing Xu, Weidong Li, Fangfang Liu and Li Fu

  Cancer Biology & Medicine May 2021, 18 (2) 477-489; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0422
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  Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases

  Zhen Zhou, Zichuan Liu, Qiuxiang Ou, Xue Wu, Xiaonan Wang, Yang Shao, Hongyan Liu and Yu Yang

  Cancer Biology & Medicine May 2021, 18 (2) 490-501; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0120
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  Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas

  Giacomo Miserocchi, Claudia Cocchi, Alessandro De Vita, Chiara Liverani, Chiara Spadazzi, Sebastiano Calpona, Giandomenico Di Menna, Massimo Bassi, Giuseppe Meccariello, Giovanni De Luca, Angelo Campobassi, Maria Maddalena Tumedei, Alberto Bongiovanni, Valentina Fausti, Franco Cotelli, Toni Ibrahim and Laura Mercatali

  Cancer Biology & Medicine May 2021, 18 (2) 502-516; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0482
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  A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma

  Qiujuan Huang, Tongyuan Qu, Lisha Qi, Changxu Liu, Yuhong Guo, Qianru Guo, Guangning Li, Yalei Wang, Wenshuai Zhang, Wei Zhao, Danyang Ren, Leina Sun, Shengguang Wang, Bin Meng, Baocun Sun, Bin Zhang, Wenjuan Ma and Wenfeng Cao

  Cancer Biology & Medicine May 2021, 18 (2) 517-529; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0648
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  Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis

  Zhen Ni, Wenquan Lu, Qi Li, Chuan Han, Ting Yuan, Nina Sun and Yongquan Shi

  Cancer Biology & Medicine May 2021, 18 (2) 530-546; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0131
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  L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma

  Xuan Zhao, Shasha Liu, Xinfeng Chen, Jianyi Zhao, Feng Li, Qitai Zhao, Tan Xie, Lan Huang, Zhen Zhang, Yu Qi, Yang Yang, Song Zhao and Yi Zhang

  Cancer Biology & Medicine May 2021, 18 (2) 547-561; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0182
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  The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma

  Yan Song, Juxiang Xiao, Wentao Fang, Ping Lu, Qingxia Fan, Yongqian Shu, Jifeng Feng, Shu Zhang, Yi Ba, Yang Zhao, Ying Liu, Chunmei Bai, Yuxian Bai, Yong Tang, Jie He and Jing Huang

  Cancer Biology & Medicine May 2021, 18 (2) 562-568; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0187
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  CD13 inhibition augments DR4-induced tumor cell death in a p-ERK1/2-independent manner

  Jun Ni, Xiaofei Wang, Yue Shang, Yi Li and Shuzhen Chen

  Cancer Biology & Medicine May 2021, 18 (2) 569-586; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0196
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  LncRNA HIF1A-AS2 accelerates malignant phenotypes of renal carcinoma by modulating miR-30a-5p/SOX4 axis as a ceRNA

  Mingwei Chen, Xuedong Wei, Xiu Shi, Le Lu, Guangbo Zhang, Yuhua Huang and Jianquan Hou

  Cancer Biology & Medicine May 2021, 18 (2) 587-603; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0209
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  A novel expressed prostatic secretion (EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer

  Denise Drago, Annapaola Andolfo, Ettore Mosca, Alessandro Orro, Luigi Nocera, Vito Cucchiara, Matteo Bellone, Francesco Montorsi and Alberto Briganti

  Cancer Biology & Medicine May 2021, 18 (2) 604-615; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0617
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  Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer

  Huizhi Sun, Danfang Zhang, Chongbiao Huang, Yuhong Guo, Zhao Yang, Nan Yao, Xueyi Dong, Runfen Cheng, Nan Zhao, Jie Meng, Baocun Sun and Jihui Hao

  Cancer Biology & Medicine May 2021, 18 (2) 616-630; DOI: https://doi.org/10.20892/j.issn.2095-3941.2021.0158