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Research ArticleOriginal Article

A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis

Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu and Ying Yuan
Cancer Biology & Medicine February 2021, 18 (1) 215-226; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0305
Mengyuan Yang
1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
2Cancer Institute, Zhejiang University School of Medicine, Hangzhou 310009, China
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Yingxin Zhao
1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
2Cancer Institute, Zhejiang University School of Medicine, Hangzhou 310009, China
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Yuwei Ding
1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
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Juan Wang
1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
2Cancer Institute, Zhejiang University School of Medicine, Hangzhou 310009, China
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Yinuo Tan
1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
2Cancer Institute, Zhejiang University School of Medicine, Hangzhou 310009, China
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Dong Xu
3Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
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Ying Yuan
1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
2Cancer Institute, Zhejiang University School of Medicine, Hangzhou 310009, China
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  • ORCID record for Ying Yuan
  • For correspondence: [email protected]
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Article Information

vol. 18 no. 1 215-226
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0305

Published By 
Cancer Biology & Medicine
History 
  • Received June 11, 2020
  • Accepted September 8, 2020
  • Published online February 1, 2021.

Copyright & Usage 
Copyright: © 2021, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Mengyuan Yang1,2,
  2. Yingxin Zhao1,2,
  3. Yuwei Ding1,
  4. Juan Wang1,2,
  5. Yinuo Tan1,2,
  6. Dong Xu3 and
  7. Ying Yuan1,2⇑
  1. 1Department of Medical Oncology, Zhejiang University School of Medicine, Hangzhou 310009, China
  2. 2Cancer Institute, Zhejiang University School of Medicine, Hangzhou 310009, China
  3. 3Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  1. Correspondence to: Ying Yuan, E-mail: yuanying1999{at}zju.edu.cn
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Cancer Biology and Medicine: 18 (1)
Cancer Biology & Medicine
Vol. 18, Issue 1
1 Feb 2021
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A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis
Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu, Ying Yuan
Cancer Biology & Medicine Feb 2021, 18 (1) 215-226; DOI: 10.20892/j.issn.2095-3941.2020.0305

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A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis
Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu, Ying Yuan
Cancer Biology & Medicine Feb 2021, 18 (1) 215-226; DOI: 10.20892/j.issn.2095-3941.2020.0305
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Keywords

  • Adenomatous polyposis
  • DUOX2
  • whole-exome sequencing
  • endoplasmic reticulum retention
  • unfolded protein response

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