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Research ArticleOriginal Article

Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library

Yuanzhong Wu, Liwen Zhou, Zifeng Wang, Xin Wang, Ruhua Zhang, Lisi Zheng and Tiebang Kang
Cancer Biology & Medicine August 2020, 17 (3) 782-794; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0162
Yuanzhong Wu
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Liwen Zhou
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Zifeng Wang
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Xin Wang
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Ruhua Zhang
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Lisi Zheng
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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Tiebang Kang
1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
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  • ORCID record for Tiebang Kang
  • For correspondence: kangtb{at}sysucc.org.cn
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Article Information

vol. 17 no. 3 782-794
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0162

Published By 
Cancer Biology & Medicine
History 
  • Published online August 15, 2020.

Copyright & Usage 
Copyright: © 2020, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Yuanzhong Wu1,*,
  2. Liwen Zhou1,*,
  3. Zifeng Wang1,
  4. Xin Wang1,
  5. Ruhua Zhang1,
  6. Lisi Zheng1 and
  7. Tiebang Kang1⇑
  1. 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
  1. Correspondence to: Tiebang Kang, E-mail: kangtb{at}sysucc.org.cn
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Cancer Biology and Medicine: 17 (3)
Cancer Biology & Medicine
Vol. 17, Issue 3
15 Aug 2020
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Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library
Yuanzhong Wu, Liwen Zhou, Zifeng Wang, Xin Wang, Ruhua Zhang, Lisi Zheng, Tiebang Kang
Cancer Biology & Medicine Aug 2020, 17 (3) 782-794; DOI: 10.20892/j.issn.2095-3941.2020.0162

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Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library
Yuanzhong Wu, Liwen Zhou, Zifeng Wang, Xin Wang, Ruhua Zhang, Lisi Zheng, Tiebang Kang
Cancer Biology & Medicine Aug 2020, 17 (3) 782-794; DOI: 10.20892/j.issn.2095-3941.2020.0162
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Keywords

  • osteosarcoma
  • kinase
  • CRISPR-Cas9 library
  • TRRAP
  • PKMYT1
  • TP53RK

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