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Research ArticleOriginal Article

Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer

Runsen Jin, Chengming Liu, Sufei Zheng, Xinfeng Wang, Xiaoli Feng, Hecheng Li, Nan Sun and Jie He
Cancer Biology & Medicine August 2020, 17 (3) 768-781; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0121
Runsen Jin
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Chengming Liu
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Sufei Zheng
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Xinfeng Wang
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Xiaoli Feng
3Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Hecheng Li
2Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Nan Sun
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • ORCID record for Nan Sun
  • For correspondence: sunnan{at}vip.126.com prof.jiehe{at}gmail.com
Jie He
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • ORCID record for Jie He
  • For correspondence: sunnan{at}vip.126.com prof.jiehe{at}gmail.com
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Article Information

vol. 17 no. 3 768-781
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0121

Published By 
Cancer Biology & Medicine
History 
  • Received March 26, 2020
  • Accepted June 28, 2020
  • Published online August 15, 2020.

Copyright & Usage 
Copyright: © 2020, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Runsen Jin1,2,*,
  2. Chengming Liu1,*,
  3. Sufei Zheng1,
  4. Xinfeng Wang1,
  5. Xiaoli Feng3,
  6. Hecheng Li2,
  7. Nan Sun1⇑ and
  8. Jie He1⇑
  1. 1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  2. 2Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  3. 3Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  1. Correspondence to: Nan Sun and Jie He, E-mail: sunnan{at}vip.126.com and prof.jiehe{at}gmail.com
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Cancer Biology and Medicine: 17 (3)
Cancer Biology & Medicine
Vol. 17, Issue 3
15 Aug 2020
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Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer
Runsen Jin, Chengming Liu, Sufei Zheng, Xinfeng Wang, Xiaoli Feng, Hecheng Li, Nan Sun, Jie He
Cancer Biology & Medicine Aug 2020, 17 (3) 768-781; DOI: 10.20892/j.issn.2095-3941.2020.0121

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Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer
Runsen Jin, Chengming Liu, Sufei Zheng, Xinfeng Wang, Xiaoli Feng, Hecheng Li, Nan Sun, Jie He
Cancer Biology & Medicine Aug 2020, 17 (3) 768-781; DOI: 10.20892/j.issn.2095-3941.2020.0121
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Keywords

  • NSCLC
  • East Asian
  • oncogene mutations
  • PD-1/PD-L1 inhibitors
  • immune microenvironment

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