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Review ArticleReview

Zinc dysregulation in cancers and its potential as a therapeutic target

Jie Wang, Huanhuan Zhao, Zhelong Xu and Xinxin Cheng
Cancer Biology & Medicine August 2020, 17 (3) 612-625; DOI: https://doi.org/10.20892/j.issn.2095-3941.2020.0106
Jie Wang
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
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Huanhuan Zhao
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
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Zhelong Xu
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
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Xinxin Cheng
1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
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  • ORCID record for Xinxin Cheng
  • For correspondence: chengxinxin{at}tmu.edu.cn
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Article Information

vol. 17 no. 3 612-625
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2020.0106

Published By 
Cancer Biology & Medicine
History 
  • Received March 12, 2020
  • Accepted June 8, 2020
  • Published online August 15, 2020.

Copyright & Usage 
Copyright: © 2020, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Jie Wang1,*,
  2. Huanhuan Zhao1,*,
  3. Zhelong Xu1 and
  4. Xinxin Cheng1⇑
  1. 1Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
  1. Correspondence to: Xinxin Cheng, E-mail: chengxinxin{at}tmu.edu.cn
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Cancer Biology and Medicine: 17 (3)
Cancer Biology & Medicine
Vol. 17, Issue 3
15 Aug 2020
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Zinc dysregulation in cancers and its potential as a therapeutic target
Jie Wang, Huanhuan Zhao, Zhelong Xu, Xinxin Cheng
Cancer Biology & Medicine Aug 2020, 17 (3) 612-625; DOI: 10.20892/j.issn.2095-3941.2020.0106

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Zinc dysregulation in cancers and its potential as a therapeutic target
Jie Wang, Huanhuan Zhao, Zhelong Xu, Xinxin Cheng
Cancer Biology & Medicine Aug 2020, 17 (3) 612-625; DOI: 10.20892/j.issn.2095-3941.2020.0106
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  • Article
    • Abstract
    • Introduction
    • Zinc signaling
    • Regulation of zinc homeostasis
    • Zinc transporters and zinc signaling in cancer
    • Zinc deficiency is an increased cancer risk
    • Dysregulation of zinc metabolism in cancer
    • Zinc transporters and cancer
    • Zinc signaling in other cancers
    • Clinical applications of zinc and zinc transporters
    • Conclusions and perspectives
    • Supporting Information
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
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Keywords

  • cancer
  • cancer therapy
  • zinc homeostasis
  • zinc transporter

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